MDMA 治疗军队人群的 PTSD 和神经康复。
MDMA for treatment of PTSD and neurorehabilitation in military populations.
机构信息
Department of Veteran Affairs, VISN-22 Mental Illness Research Education Clinical Center, Los Angeles, CA, USA.
Semel Institute for Neuroscience and Human Behavior, University of California - Los Angeles, Los Angeles, CA, USA.
出版信息
NeuroRehabilitation. 2024;55(3):357-368. doi: 10.3233/NRE-230270.
BACKGROUND
Neurorehabilitation in military populations is complicated by higher rates of PTSD and unique characteristics of military institutions. These factors can adversely impact the patient-therapist therapeutic alliance and engagement with the rehabilitation process leading to poorer outcomes. MDMA is a non-classical psychedelic with pro-social and fear regulating properties. MDMA-assisted therapy is being explored as a novel treatment for PTSD that potentially offers rapid symptom improvement and enhances therapeutic alliance.
OBJECTIVE
A review of MDMA-assisted therapy for PTSD is provided in the context of neurorehabilitation in military populations. The molecular mechanism of MDMA is outlined and a novel application of MDMA for neurorehabilitation is proposed.
METHODS
This is an expert review and synthesis of the literature.
RESULTS
Results from late-stage clinical trials suggest MDMA-assisted therapy for PTSD would be of particular benefit for military populations with PTSD. The unique pro-social properties of MDMA could be leveraged to enhance the therapeutic alliance and patient engagement during neurorehabilitation.
CONCLUSION
The unique qualities and benefits of MDMA and MDMA-assisted therapy for PTSD suggest relevant application in military personnel undergoing neurorehabilitation. There are many similarities in patient-therapist dynamics in PTSD treatment and neurorehabilitation. The properties of MDMA which enhance therapeutic alliance, downregulate fear, and increase cognitive flexibility would potentially benefit both military personnel with and without PTSD undergoing neurorehabilitation.
背景
军事人群中的神经康复受到 PTSD 发生率较高和军事机构独特特征的影响。这些因素可能会对患者与治疗师的治疗联盟以及对康复过程的参与产生不利影响，导致治疗效果较差。MDMA 是一种具有亲社会和恐惧调节特性的非典型迷幻剂。MDMA 辅助疗法正被探索用于治疗 PTSD，它可能会带来更快的症状改善，并增强治疗联盟。
目的
在军事人群的神经康复背景下，对 MDMA 辅助治疗 PTSD 进行综述。概述了 MDMA 的分子机制，并提出了 MDMA 在神经康复中的新应用。
方法
这是一篇专家综述和文献综合。
结果
晚期临床试验的结果表明，MDMA 辅助治疗 PTSD 对 PTSD 军事人群特别有益。MDMA 的独特亲社会特性可以被利用来增强神经康复期间的治疗联盟和患者参与度。
结论
MDMA 及其在 PTSD 治疗中的辅助治疗的独特性质和益处表明，其在接受神经康复的军人中具有相关应用。在 PTSD 治疗和神经康复中，患者与治疗师之间的动态存在许多相似之处。增强治疗联盟、下调恐惧和提高认知灵活性的 MDMA 特性可能对 PTSD 患者和未患 PTSD 的接受神经康复的军人都有好处。
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