Department of Head & Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Department of Esophageal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Future Oncol. 2024;20(36):2849-2854. doi: 10.1080/14796694.2024.2398985. Epub 2024 Sep 27.
Treatment options for esophageal squamous cell carcinoma includes surgery and chemoradiotherapy (CRT), however there was limited information about the factors influenced in patients' decision-making. Patients who participated in JCOG0502, a parallel group controlled trial comparing surgery with CRT, were analyzed for the factors related to decision-making. Of the 368 patients (pts) enrolled in the nonrandomized part in JCOG0502, 209 pts opted for surgery and 159 pts chose CRT on their own. Background characteristics were the same except for age. Multivariable logistic regression analysis showed that age ≥65 years, male sex, multiple lesions, absence of children and doctor's thinking were associated with the selection of CRT. The doctor's option was the most influential factor in the patient's decision-making process. UMIN000000551 (ClinicalTrials.gov).
食管鳞状细胞癌的治疗选择包括手术和放化疗（CRT），但关于影响患者决策的因素信息有限。参与 JCOG0502 的患者，该研究为一项比较手术与 CRT 的平行组对照试验，对与决策相关的因素进行了分析。在 JCOG0502 的非随机部分纳入的 368 例患者（pts）中，209 例 pts 选择手术，159 例 pts 自行选择 CRT。除年龄外，背景特征相同。多变量逻辑回归分析显示，年龄≥65 岁、男性、多发病灶、无子女和医生的想法与 CRT 的选择有关。医生的选择是患者决策过程中最具影响力的因素。UMIN000000551（ClinicalTrials.gov）。
