Reed J, Bradley E L
Surgery. 1985 Nov;98(5):983-6.
Lithium carbonate is a known antithyroid agent that acts primarily to inhibit the release of preformed thyroid hormone. Lithium was chosen for preoperative preparation in a noncompliant patient with Graves' Disease who was not able to tolerate any other antithyroid agents. Despite excellent preoperative control, postoperative thyroid storm developed. This is the first reported case of the use of lithium for preoperative preparation. Since it is possible that surgical manipulation caused the demonstrated release of preformed hormone and subsequent postoperative storm, caution in the sole use of this agent for preoperative preparation seems warranted.
碳酸锂是一种已知的抗甲状腺药物，其主要作用是抑制预先形成的甲状腺激素的释放。对于一名患有格雷夫斯病且不依从治疗、无法耐受任何其他抗甲状腺药物的患者，选择了锂进行术前准备。尽管术前控制良好，但术后仍发生了甲状腺危象。这是首例报道使用锂进行术前准备的病例。由于手术操作可能导致了预先形成的激素的释放及随后的术后危象，因此仅使用该药物进行术前准备时似乎应谨慎。
