Kauschansky A, Genel M
Department of Pediatrics, Yale University School of Medicine, Yale-New Haven Hospital, Conn., USA.
Eur J Pediatr Surg. 1996 Oct;6(5):301-2. doi: 10.1055/s-2008-1071002.
We present a 15-year-old girl with an unusual clinical course of intractable thyrotoxicosis that was resistant to thiocarbamide therapy and propranolol. Although the latter beta-adrenergic blocking agent has been used as the sole drug in the preparation of thyrotoxicosis patients for thyroidectomy, it was unsatisfactory for control of our case. In contrast, the patient's clinical response to lithium carbonate 900-1500 mg/d for 10 days was very good and no side effects were observed. This demonstrates the importance of lithium as the drug of choice in thyrotoxic emergencies and uncontrolled preoperative patients when rapid and safe inhibition of thyroid hormone secretion is required.
我们报告一名15岁女孩，患有难治性甲状腺毒症，临床病程不寻常，对硫脲类药物治疗和普萘洛尔耐药。尽管后一种β-肾上腺素能阻滞剂已被用作甲状腺毒症患者甲状腺切除术前的单一用药，但对我们的病例控制效果并不理想。相比之下，该患者每日服用900 - 1500毫克碳酸锂，持续10天，临床反应非常良好，且未观察到副作用。这表明，在甲状腺毒症急症以及术前未得到控制且需要快速安全抑制甲状腺激素分泌的患者中，锂作为首选药物具有重要意义。
