一种新的红细胞冷自身抗体（抗-Me）。

A new red blood cell cold autoantibody (anti-Me).

作者信息

Salama A, Pralle H, Mueller-Eckhardt C

出版信息

Vox Sang. 1985;49(4):277-84. doi: 10.1111/j.1423-0410.1985.tb01122.x.

DOI:10.1111/j.1423-0410.1985.tb01122.x

Abstract

A new red blood cell (RBC) cold autoantibody (anti-Me) is presented which was detected in a patient with autoimmune hemolytic anemia of 'cold type' associated with Waldenström's macroglobulinemia. The autoantibody was of the IgM (Kappa) class, had a moderate titer, and reacted with cord as well as with adult RBC. Its hemagglutinating activity against RBC was markedly increased in the presence of preheated human milk, but not in the presence of simple sugars or preheated casein. The data suggest that the antibody is directed against a new (glycolipid) antigen common to human RBC termed Me antigen ('milk enhanced').

摘要

本文报告了一种新的红细胞（RBC）冷自身抗体（抗-Me），该抗体在一名与华氏巨球蛋白血症相关的“冷型”自身免疫性溶血性贫血患者中被检测到。该自身抗体为IgM（κ）类，滴度中等，与脐带血红细胞以及成人红细胞均发生反应。在预热的人乳存在的情况下，其对红细胞的血凝活性显著增加，但在单糖或预热酪蛋白存在的情况下则不然。数据表明，该抗体针对的是一种人类红细胞共有的新（糖脂）抗原，称为Me抗原（“乳增强型”）。