Hinterhuber H, Neumann R
Wien Med Wochenschr. 1985 Sep 30;135(18):435-41.
In the present study two groups of 30 patients were compared. The first group included 30 acute schizophrenic patients, who were rated immediately after admission and 3 months later under depot-neuroleptics. The second group consisted of chronic schizophrenic outpatients, who were rated at the beginning of Fluphenazindecanoat-medication and 8 months later. As documentation PSE (present state examination) was used. Psychotic symptoms of the acute schizophrenic patients could be influenced well by the treatment, not in the same way, however, depressive and neurotic symptoms. The frequency of psychotic symptoms is lower in chronic schizophrenics than in acute ones at the beginning of therapy. 8 months later there are little more psychotic symptoms in chronic patients than in acute schizophrenics; the depressive symptoms follow the same design in a lower extant however. The scores of depressive symptoms in the acute-group are similar to those of chronic schizophrenics and do not change significantly in the course of 8 months lasting depot-neuroleptic therapy. Another study could show 1982, that 67 outpatients from 87 in the year 1972 still were in psychiatric care and control, 23% of them received antidepressiva because of depressive symptoms in connection with residual syndromes and only 4% because of exhaustion-syndromes after remission of the disease.
在本研究中,对两组各30名患者进行了比较。第一组包括30名急性精神分裂症患者,他们在入院后立即接受评估,并在使用长效抗精神病药物3个月后再次评估。第二组由慢性精神分裂症门诊患者组成,他们在开始使用氟奋乃静癸酸酯治疗时接受评估,并在8个月后再次评估。使用PSE(现况检查)作为记录方法。急性精神分裂症患者的精神病症状可以通过治疗得到很好的改善,但抑郁和神经症症状的改善方式不同。在治疗开始时,慢性精神分裂症患者的精神病症状频率低于急性患者。8个月后,慢性患者的精神病症状比急性精神分裂症患者略多;抑郁症状的变化趋势相同,但程度较低。急性组的抑郁症状评分与慢性精神分裂症患者相似,在持续8个月的长效抗精神病药物治疗过程中没有显著变化。另一项研究表明,1982年,1972年的87名门诊患者中有67名仍在接受精神科护理和管控,其中23%因残留综合征相关的抑郁症状而接受抗抑郁药物治疗,只有4%因疾病缓解后的疲劳综合征而接受治疗。