分枝杆菌中利福平与氯法齐明交叉耐药的可能性——一项实验室研究
On the possibility of cross-resistance between rifampicin and clofazimine in mycobacteria--a laboratory study.
作者信息
Urbanczik R
出版信息
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Aug;260(1):113-6. doi: 10.1016/s0176-6724(85)80106-1.
One-way cross-resistance to rifampicin in clofazimine-resistant substrains of Mycobacterium smegmatis ATCC 607 was seen in 4 instances, whereas at most a borderline situation (probably within the experimental error) occurred in this respect with Mycobacterium parafortuitum 16009 and with strains of Mycobacterium "lufu" and Mycobacterium fortuitum. Clofazimine-resistant sub-strains were not isolated from the parental strains of Mycobacterium tuberculosis. Methodological influences (the gradient plate technique was used in this study) are discussed.
在耻垢分枝杆菌ATCC 607的氯法齐明耐药亚菌株中，有4例出现了对利福平的单向交叉耐药，而在偶然分枝杆菌16009以及“鲁夫”分枝杆菌和偶然分枝杆菌菌株中，在这方面最多出现了一种临界情况（可能在实验误差范围内）。未从结核分枝杆菌的亲本菌株中分离出氯法齐明耐药亚菌株。文中讨论了方法学影响（本研究使用了梯度平板技术）。
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