Marinis E, Legakis N J
J Antimicrob Chemother. 1985 Oct;16(4):527-30. doi: 10.1093/jac/16.4.527.
The activity of ciprofloxacin against 42 clinical isolates of mycobacteria was studied in vitro by the 1% standard proportion method on Lowenstein-Jensen medium. Ciprofloxacin was found active against all strains of Mycobacterium tuberculosis sensitive to streptomycin, isoniazid, ethambutol and rifampicin. The MIC of ciprofloxacin was 3.2 mg/l. This concentration of ciprofloxacin was sufficient to inhibit almost all strains showing intermediate sensitivity or resistance to one or more of the above agents. The same phenomenon was also observed with the atypical isolates.
采用1%标准比例法在罗-琴培养基上，对环丙沙星针对42株临床分枝杆菌分离株的活性进行了体外研究。发现环丙沙星对所有对链霉素、异烟肼、乙胺丁醇和利福平敏感的结核分枝杆菌菌株均有活性。环丙沙星的最低抑菌浓度为3.2mg/L。该浓度的环丙沙星足以抑制几乎所有对上述一种或多种药物表现出中度敏感性或耐药性的菌株。在非典型分离株中也观察到了同样的现象。
