Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Addict Behav. 2025 Jan;160:108178. doi: 10.1016/j.addbeh.2024.108178. Epub 2024 Sep 26.
IQOS, a heated tobacco product (HTP), is among a growing number of noncombustible nicotine delivery alternatives marketed to people who smoke combustible cigarettes and are interested in less harmful alternatives. Little is known regarding whether IQOS use and IQOS-associated effects impact motivation to quit cigarette smoking.
Non-treatment-seeking adult daily smokers (n = 87) completed a within-subjects study consisting of a baseline ad-lib smoking period (days 1-5), two laboratory visits (days 6-7) involving IQOS exposure, and a two-week period where participants were instructed to switch from smoking cigarettes to using IQOS (days 8-21). Motivation to quit smoking was measured on days 1 and 22.
A generalized linear model revealed a significant increase in motivation to quit smoking across the 14-day switch phase with an increase of 1.47 ladder steps (Δ=1.47, sd = 1.98, t(86) = 6.92, p < 0.0001), increasing from 5.30 to 6.80. Candidate predictors were identified through a stepwise selection procedure, which resulted in a final model with two predictors, the standardized HeatStick substitution rate (b = 0.54, (CI95% 0.13-0.95), p = 0.01) and standardized relative risk perception score (b = 0.45, (CI95% 0.04-0.85) p = 0.03), CONCLUSIONS: Among those uninterested in quitting cigarette smoking within the next month, IQOS use was associated with increased motivation to quit. Motivation to quit smoking may not be a necessary prerequisite for promoting smoking behavior change but rather bolstered by smoking behavior change in the context of HTP use. Greater perceptions of risk reduction may ultimately aid the transition from combustible to noncombustible tobacco products.
IQOS 是一种加热型烟草产品（HTP），它是越来越多的非燃烧尼古丁输送替代品之一，面向的是那些既吸烟又对危害较小的替代品感兴趣的可燃香烟消费者。目前还不太清楚 IQOS 的使用情况及其相关影响是否会影响戒烟的动机。
非治疗性寻求的成年每日吸烟者（n=87）完成了一项包含以下内容的单组研究：基线自由吸烟期（第 1-5 天）、两次实验室访问（第 6-7 天），包括 IQOS 暴露，以及两周的时间，参与者被要求从吸烟转变为使用 IQOS（第 8-21 天）。在第 1 天和第 22 天测量戒烟动机。
广义线性模型显示，在 14 天的转换阶段，戒烟动机显著增加，增加了 1.47 个梯级（Δ=1.47，sd=1.98，t（86）=6.92，p<0.0001），从 5.30 增加到 6.80。通过逐步选择程序确定了候选预测因子，最终模型中有两个预测因子，标准化 HeatStick 替代率（b=0.54，（95%置信区间 0.13-0.95），p=0.01）和标准化相对风险感知得分（b=0.45，（95%置信区间 0.04-0.85），p=0.03）。
在那些在未来一个月内不打算戒烟的人中，使用 IQOS 与戒烟动机增加有关。戒烟动机可能不是促进吸烟行为改变的必要前提，而是在 HTP 使用的背景下加强吸烟行为改变。对风险降低的更大认识最终可能有助于从可燃烟草产品向非可燃烟草产品的转变。
