Jorgensen David, Grassly Nicholas C, Pons-Salort Margarita
Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Lancet Microbe. 2025 Jan;6(1):100938. doi: 10.1016/j.lanmic.2024.07.001. Epub 2024 Sep 24.
Enterovirus D68 (EV-D68), first isolated in 1962, emerged in 2014, causing outbreaks of severe respiratory infections and acute flaccid myelitis. In this systematic review, we have compiled all available literature on age-stratified seroprevalence estimates of EV-D68. Ten studies from six countries were retained, all conducted using microneutralisation assays, despite wide variations in protocols and challenge viruses. The age profiles of seroprevalence were similar across time and regions; seroprevalence increased quickly with age, reaching roughly 100% by the age of 20 years and with no sign of decline throughout adulthood. This suggests continuous or frequent exposure of the populations to the virus, or possible cross-reactivity with other viruses. Studies with two or more cross-sectional surveys reported consistently higher seroprevalence at later timepoints, suggesting a global increase in transmission over time. This systematic review concludes that standardising serological protocols, understanding the contribution of cross-reactivity with other pathogens to the high reported seroprevalence, and quantifying individual exposure to EV-D68 over time are the main research priorities for the future.
肠道病毒D68（EV-D68）于1962年首次分离出来，2014年出现，引发了严重呼吸道感染和急性弛缓性脊髓炎的疫情。在这项系统评价中，我们汇总了所有关于EV-D68年龄分层血清阳性率估计的现有文献。保留了来自六个国家的十项研究，所有研究均采用微量中和试验进行，尽管方案和攻击病毒存在很大差异。血清阳性率的年龄分布在不同时间和地区相似；血清阳性率随年龄迅速上升，到20岁时大致达到100%，且在整个成年期没有下降迹象。这表明人群持续或频繁接触该病毒，或者可能与其他病毒发生交叉反应。进行了两项或更多横断面调查的研究一致报告称，后期时间点的血清阳性率更高，这表明随着时间推移全球传播有所增加。本系统评价得出结论，标准化血清学方案、了解与其他病原体的交叉反应对报告的高血清阳性率的贡献，以及量化个体随时间接触EV-D68的情况是未来的主要研究重点。
