Mallet Maria Christina, Trottier Sylvie, Baz Mariana, Redah Immanuel, Duvvuri Venkata R, Kozak Robert, Vachon Marie-Louise, Daigneault Patrick, Boissinot Maurice, Bergeron Michel G, Tremblay Cécile, Longtin Yves, Huletsky Ann, Gilca Rodica, Berthelot Simon, Isabel Sandra
Axe Maladies infectieuses et immunitaires, Centre de recherche du CHU de Québec-Université Laval, Québec, Canada.
Département de microbiologie-infectiologie et d'immunologie, Faculté de Médecine, Université Laval, Québec, Canada.
IJID Reg. 2025 May 14;15:100669. doi: 10.1016/j.ijregi.2025.100669. eCollection 2025 Jun.
Enterovirus D68 (EV-D68) is mainly studied in children, while data in adults are limited. We described the clinical presentation of EV-D68 in adults, compared with other enterovirus/rhinovirus (EV/RV) infections.
We used clinical and laboratory data from 1143 adults visiting four emergency departments in Quebec, Canada, for acute respiratory infections (February 2022 to March 2023). We analyzed nasopharyngeal swabs using a multiplex polymerase chain reaction; positive EV/RV samples were further tested with EV-D68-specific polymerase chain reaction assays. We calculated the Pandemic Medical Early Warning Score (PMEWS) to assess severity.
Of 155 (14%) EV/RV samples, 19 (12%) were EV-D68 and occurred from July to October, 2022. Patients with EV-D68 more frequently lived with other people (100% vs 73%, = 0.02) and tended to have more underlying chronic respiratory diseases (26% vs 20%) and respiratory symptoms (e.g., dyspnea: 84% vs 75%; wheezing: 63% vs 44%; and chest pain: 63% vs 49%), although these differences were not statistically significant. PMEWS, hospitalizations, and median time spent in the emergency department did not differ significantly between the EV-D68 and the other EV/RV group.
Respiratory symptoms tended to be more common among participants with EV-D68 than those with other EV/RV, although disease severity was similar. Larger studies are needed to better characterize EV-D68 infections in adults.
肠道病毒D68型（EV-D68）主要在儿童中进行研究，而关于成人的数据有限。我们描述了成人感染EV-D68的临床表现，并与其他肠道病毒/鼻病毒（EV/RV）感染进行比较。
我们使用了来自加拿大魁北克省四个急诊科的1143名因急性呼吸道感染就诊的成人（2022年2月至2023年3月）的临床和实验室数据。我们使用多重聚合酶链反应分析鼻咽拭子；对EV/RV阳性样本进一步用EV-D68特异性聚合酶链反应检测。我们计算了大流行医疗早期预警评分（PMEWS）以评估疾病严重程度。
在155份（14%）EV/RV样本中，19份（12%）为EV-D68，发生于2022年7月至10月。感染EV-D68的患者更常与他人同住（100%对73%，P = 0.02），并且往往有更多潜在的慢性呼吸道疾病（26%对20%）和呼吸道症状（如呼吸困难：84%对75%；喘息：63%对44%；胸痛：63%对49%），尽管这些差异无统计学意义。EV-D68组与其他EV/RV组在PMEWS、住院率和在急诊科的中位停留时间方面无显著差异。
尽管疾病严重程度相似，但EV-D68感染者的呼吸道症状往往比其他EV/RV感染者更常见。需要开展更大规模的研究以更好地描述成人EV-D68感染的特征。
