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激活表达 NPY2R 的杏仁核神经元可抑制小鼠的瘙痒行为而无偏侧性。

Activation of NPY2R-expressing amygdala neurons inhibits itch behavior in mice without lateralization.

机构信息

Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB 2063, Miami, FL, 33136, USA.

Department of Medical Pharmacology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

出版信息

Sci Rep. 2024 Sep 27;14(1):22125. doi: 10.1038/s41598-024-73483-9.

DOI:10.1038/s41598-024-73483-9
PMID:39333236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11437048/
Abstract

The central amygdala (CeA) is a crucial hub in the processing of affective itch, containing a diverse array of neuronal populations. Among these components, Neuropeptide Y (NPY) and its receptors, such as NPY2R, affect various physiological and psychological processes. Despite this broad impact, the precise role of NPY2R CeA neurons in itch modulation remains unknown, particularly concerning any potential lateralization effects. To address this, we employed optogenetics to selectively stimulate NPY2R CeA neurons in mice, investigating their impact on itch modulation. Optogenetic activation of NPY2R CeA neurons reduced scratching behavior elicited by pruritogens without exhibiting any lateralization effects. Electrophysiological recordings confirmed increased neuronal activity upon stimulation. However, this modulation did not affect thermal sensitivity, mechanical sensitivity, or formalin-induced hyperalgesia. Additionally, no alterations in anxiety-like behaviors or locomotion were observed upon stimulation. Projection tracing revealed connections of NPY2R CeA neurons to brain regions implicated in itch processing. Overall, this comprehensive study highlights the role of NPY2R CeA neurons in itch regulation without any lateralization effects.

摘要

杏仁中央核（CeA）是处理情感性瘙痒的关键中枢，包含多种神经元群体。其中，神经肽 Y（NPY）及其受体，如 NPY2R，影响着各种生理和心理过程。尽管 NPY2R CeA 神经元具有广泛的影响，但它们在瘙痒调节中的具体作用，特别是关于任何潜在的侧化效应，仍然未知。为了解决这个问题，我们采用光遗传学选择性刺激小鼠的 NPY2R CeA 神经元，研究它们对瘙痒调节的影响。光遗传学激活 NPY2R CeA 神经元可减少由致痒剂引起的搔抓行为，但没有表现出任何侧化效应。电生理记录证实刺激后神经元活动增加。然而，这种调节并不影响热敏感性、机械敏感性或福尔马林诱导的痛觉过敏。此外，刺激后观察到焦虑样行为或运动没有改变。投射示踪显示 NPY2R CeA 神经元与参与瘙痒处理的脑区之间存在联系。总的来说，这项全面的研究强调了 NPY2R CeA 神经元在瘙痒调节中的作用，而没有任何侧化效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/66c65bd2e844/41598_2024_73483_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/56cd72cfa506/41598_2024_73483_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/ea4b1763d168/41598_2024_73483_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/b356c32344a5/41598_2024_73483_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/aa23673bb4b7/41598_2024_73483_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/d4de556dfb5a/41598_2024_73483_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/66c65bd2e844/41598_2024_73483_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/56cd72cfa506/41598_2024_73483_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/ea4b1763d168/41598_2024_73483_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/b356c32344a5/41598_2024_73483_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/aa23673bb4b7/41598_2024_73483_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/d4de556dfb5a/41598_2024_73483_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c69/11437048/66c65bd2e844/41598_2024_73483_Fig11_HTML.jpg

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