安替比林和4-氨基安替比林对花生四烯酸代谢的抑制作用。
Inhibition of arachidonic acid metabolism by antipyrine and 4-aminoantipyrine.
作者信息
Cohen D, Corbin J, Figueroa J P, Nathanielsz P W, Mitchell M D
出版信息
Am J Obstet Gynecol. 1985 Nov 1;153(5):589-90. doi: 10.1016/0002-9378(85)90484-3.
PMID:3933352
Abstract
Antipyrine and 4-aminoantipyrine are used to determine uterine and umbilical blood flows. When administered in vivo, these compounds produce a decrease in uterine contracture activity and maternal uterine vein 13,14-dihydro-15-keto-prostaglandin F2 alpha concentrations. In this paper we report that they also inhibit in vitro activity of prostaglandin synthase in bovine seminal microsomes.
摘要
安替比林和4-氨基安替比林用于测定子宫和脐血流量。当在体内给药时，这些化合物会使子宫挛缩活动和母体子宫静脉中13,14-二氢-15-酮-前列腺素F2α浓度降低。在本文中，我们报道它们还能抑制牛精囊微粒体中前列腺素合酶的体外活性。
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