Halevy O, Sklan D
Biochim Biophys Acta. 1987 Apr 24;918(3):304-7. doi: 10.1016/0005-2760(87)90235-9.
Prostaglandin and hydroxyeicosatetraenoic acid (HETE) production from arachidonic acid in bovine seminal vesicles and kidney as influenced by the addition of beta-carotene, retinol or alpha-tocopherol was studied. The major product formed was prostaglandin E2 (approximately 85% prostaglandin E2 of control), and its proportion decreased with increasing concentration of the additives, while the proportion of HETE increased. Prostaglandin and HETE production was considerably inhibited by beta-carotene and retinol, and to a lesser extent by alpha-tocopherol; HETE production was inhibited less than that of prostaglandin. It appears that beta-carotene, retinol and alpha-tocopherol influence both the cyclooxygenase and lipoxygenase pathways; this modulation of arachidonic acid oxidation by physiological compounds may have important in vivo implications.
研究了添加β-胡萝卜素、视黄醇或α-生育酚对牛精囊和肾脏中花生四烯酸生成前列腺素和羟基二十碳四烯酸（HETE）的影响。形成的主要产物是前列腺素E2（约占对照的85%前列腺素E2），其比例随着添加剂浓度的增加而降低，而HETE的比例增加。β-胡萝卜素和视黄醇可显著抑制前列腺素和HETE的生成，α-生育酚的抑制作用较小；HETE生成的抑制程度小于前列腺素。似乎β-胡萝卜素、视黄醇和α-生育酚会影响环氧化酶和脂氧化酶途径；生理化合物对花生四烯酸氧化的这种调节可能在体内具有重要意义。
