Mićić S, Dotlić R
Andrologia. 1985 Sep-Oct;17(5):502-7. doi: 10.1111/j.1439-0272.1985.tb01049.x.
According to higher androgen insensitivity index than in fertile men, the group of 83 men, with high serum LH and high or normal testosterone levels, was separated from 800 infertile men. These patients with high androgen insensitivity index had oligozoospermia (6.38 +/- 3.18 X 10(6)/ml) or azoospermia. They had significantly higher serum LH and testosterone levels than compared groups of infertile and fertile men. Elevated serum FSH levels in infertile men with high androgen insensitivity index showed damage of spermatogenesis. There was completely disturbed hypothalamo-pituitary-testicular axis as the serum prolactin levels were significantly elevated too. There was no significant difference in serum estradiol levels among investigated groups. Using androgen insensitivity index we could identify those men whose infertility is not treatable.
根据雄激素不敏感指数高于生育男性,从800名不育男性中分离出83名血清促黄体生成素(LH)水平高且睾酮水平高或正常的男性。这些雄激素不敏感指数高的患者患有少精子症(6.38±3.18×10⁶/ml)或无精子症。他们的血清LH和睾酮水平明显高于不育和生育男性的对照组。雄激素不敏感指数高的不育男性血清促卵泡生成素(FSH)水平升高表明生精功能受损。由于血清催乳素水平也显著升高,下丘脑-垂体-睾丸轴完全紊乱。各研究组之间血清雌二醇水平无显著差异。利用雄激素不敏感指数,我们可以识别出那些不育无法治疗的男性。