Choi Dong-Hee, Choi In-Ae, Lee Jongmin
Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul 05029, Republic of Korea.
Department of Medical Science, Konkuk University School of Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Antioxidants (Basel). 2024 Aug 30;13(9):1065. doi: 10.3390/antiox13091065.
Stroke is one of the most significant causes of death and long-term disability globally. Overproduction of reactive oxygen species by NADPH oxidase (NOX) plays an important role in exacerbating oxidative stress and causing neuronal damage after a stroke. There is growing evidence that NOX inhibition prevents ischemic injury and that the role of NOX in brain damage or recovery depends on specific post-stroke phases. In addition to studies on post-stroke neuroprotection by NOX inhibition, recent reports have also demonstrated the role of NOX in stroke recovery, a critical process for brain adaptation and functional reorganization after a stroke. Therefore, in this review, we investigated the role of NOX in stroke recovery with the aim of integrating preclinical findings into potential therapeutic strategies to improve stroke recovery.
中风是全球范围内导致死亡和长期残疾的最重要原因之一。烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NOX）产生的活性氧过量在中风后加剧氧化应激和导致神经元损伤方面起着重要作用。越来越多的证据表明，抑制NOX可预防缺血性损伤，并且NOX在脑损伤或恢复中的作用取决于中风后的特定阶段。除了关于抑制NOX对中风后神经保护作用的研究外，最近的报告还证明了NOX在中风恢复中的作用，中风恢复是中风后大脑适应和功能重组的关键过程。因此，在本综述中，我们研究了NOX在中风恢复中的作用，目的是将临床前研究结果整合到潜在的治疗策略中，以改善中风恢复情况。
