TSG通过靶向DAF-16/SKN-1/SIR-2.1介导的线粒体质量控制过程延长寿命。

TSG Extends the Longevity of by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process.

作者信息

Sun Menglu, Wei Congmin, Gao Yehui, Chen Xinyan, Zhong Kaixin, Li Yingzi, Yang Zhou, Gao Yihuai, Wang Hongbing

机构信息

Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

Tongji Alpha Natural Medicine Research Institute, Tongji University, Shanghai 200070, China.

出版信息

Antioxidants (Basel). 2024 Sep 4;13(9):1086. doi: 10.3390/antiox13091086.

DOI:10.3390/antiox13091086

PMID:39334745

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11428426/

Abstract

The improvement of mitochondrial function is described as a strategy for alleviating oxidative stress and intervening in the aging process. 2,3,5,4'-Tetrahydroxystilbene-2---D-glucoside (TSG) is one of the major bioactive components isolated from Thunb, and it exhibits multiple activities, including antioxidant and anti-inflammatory effects. In this study, we found that 200 μM TSG significantly extended the mean lifespan of by 16.48% and improved health status by delaying age-associated physiological decline in worms. The longevity prolongation effect of TSG depended on the regulation of the mitochondrial quality control process mediated by DAF-16/FOXO, SKN-1/Nrf2 and SIR-2.1/SIRT1 to improve mitochondrial function. Moreover, TSG treatment obviously alleviated the proteotoxicity of β-amyloid and tau proteins in worms. Our findings indicated that TSG is a promising natural product for preventing aging and treating aging-associated neurodegenerative diseases by regulating the mitochondrial quality control process to improve mitochondrial function.

摘要

线粒体功能的改善被描述为减轻氧化应激和干预衰老过程的一种策略。2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷（TSG）是从何首乌中分离出的主要生物活性成分之一，它具有多种活性，包括抗氧化和抗炎作用。在本研究中，我们发现200μM的TSG显著延长了线虫的平均寿命达16.48%，并通过延缓线虫与年龄相关的生理衰退来改善其健康状况。TSG的长寿延长作用依赖于由DAF-16/FOXO、SKN-1/Nrf2和SIR-2.1/SIRT1介导的线粒体质量控制过程的调节，以改善线粒体功能。此外，TSG处理明显减轻了线虫中β-淀粉样蛋白和tau蛋白的蛋白毒性。我们的研究结果表明，TSG是一种有前景的天然产物，可通过调节线粒体质量控制过程来改善线粒体功能，从而预防衰老和治疗与衰老相关的神经退行性疾病。