Jiangxi Province Key Laboratory of Immunity and Inflammation, Jiangxi Provincial People's Hospital, Nanchang 330000, China.
Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, China.
Biomolecules. 2024 Aug 25;14(9):1054. doi: 10.3390/biom14091054.
Systemic sclerosis (SSc) is a chronic disease of the connective tissue characterized by its multifaceted impact on various bodily systems, yet its precise cause remains elusive. Central to its pathology are abnormal immune activation, vasculopathy, and consequent fibrosis affecting both the skin and internal organs. The intricate interplay between the innate and adaptive immune systems significantly influences the pathogenesis of SSc. Despite substantial research, the role of neutrophils, key players in innate immunity, in the context of SSc has remained enigmatic. Emerging evidence suggests that neutrophils not only contribute to the initiation and perpetuation of SSc but also inflict damage on organs and promote fibrosis-a hallmark of the disease in many patients. This review aims to investigate the nuanced involvement of neutrophils in the development of SSc. By shedding light on the intricate mechanisms through which neutrophils influence the pathogenesis of SSc, we can gain deeper insights into the disease process and potentially identify novel therapeutic targets. Understanding the precise role of neutrophils may pave the way for more targeted and effective interventions to alleviate the burden of SSc on affected individuals.
系统性硬化症（SSc）是一种结缔组织的慢性疾病，其特征是对各种身体系统产生多方面的影响，但确切的病因仍难以捉摸。其病理的核心是异常的免疫激活、血管病变以及随后影响皮肤和内脏器官的纤维化。先天免疫和适应性免疫系统之间的复杂相互作用极大地影响了 SSc 的发病机制。尽管进行了大量研究，但中性粒细胞在 SSc 背景下的作用，作为先天免疫的关键参与者，仍然是一个谜。新出现的证据表明，中性粒细胞不仅有助于 SSc 的启动和持续，而且还会对器官造成损害并促进纤维化——这是许多患者疾病的一个标志。本综述旨在探讨中性粒细胞在 SSc 发展中的细微作用。通过阐明中性粒细胞影响 SSc 发病机制的复杂机制，我们可以更深入地了解疾病过程，并有可能确定新的治疗靶点。了解中性粒细胞的确切作用可能为更有针对性和有效的干预措施铺平道路，以减轻受影响个体的 SSc 负担。
