Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary.
Biomolecules. 2024 Aug 25;14(9):1052. doi: 10.3390/biom14091052.
Researchers are paying increasing attention to the strongly negatively charged heteropolysaccharides in cells, in the extracellular matrix or in the cell wall. Examples of such molecules are glycosaminoglycans (e.g., heparin, heparan sulphate). It is well known from the literature that heparin and its derivatives have anti-inflammatory, angiogenic, metastatic and growth factor inhibitory activity. Herein, we present the efficient synthesis of six non-glycosaminoglycan (Glc-GlcA-Glc-sequenced) and one heparin-related (GlcN-GlcA-Glc-sequenced) trisaccharides with various functional group patterns. The anti-inflammatory, antioxidant and cell growth-inhibitory/cytotoxic effects of the synthesized compounds were tested. Among the investigated molecules, we have found some derivatives with a promising anti-inflammatory and antioxidant effect.
研究人员越来越关注细胞、细胞外基质或细胞壁中带强负电荷的杂多糖。此类分子的例子有糖胺聚糖（例如肝素、硫酸乙酰肝素）。文献中已知肝素及其衍生物具有抗炎、血管生成、转移和生长因子抑制活性。在此，我们展示了六种非糖胺聚糖（Glc-GlcA-Glc 序列）和一种肝素相关（GlcN-GlcA-Glc 序列）三糖的高效合成，它们具有各种功能基团模式。测试了合成化合物的抗炎、抗氧化和抑制细胞生长/细胞毒性作用。在所研究的分子中，我们发现一些具有有前途的抗炎和抗氧化作用的衍生物。
