Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502284, Telangana, India.
Institute for Frontier Materials, Deakin University, Geelong, VIC 3216, Australia.
Biomolecules. 2024 Aug 28;14(9):1082. doi: 10.3390/biom14091082.
Opportunistic pathogenic microbial infections pose a significant danger to human health, which forces people to use riskier, more expensive, and less effective drugs compared to traditional treatments. These may be attributed to several factors, such as overusing antibiotics in medicine and lack of sanitization in hospital settings. In this context, researchers are looking for new options to combat this worrying condition and find a solution. Nanoparticles are currently being utilized in the pharmaceutical sector; however, there is a persistent worry regarding their potential danger to human health due to the usage of toxic chemicals, which makes the utilization of nanoparticles highly hazardous to eukaryotic cells. Multiple nanoparticle-based techniques are now being developed, offering essential understanding regarding the synthesis of components that play a crucial role in producing anti-microbial nanotherapeutic pharmaceuticals. In this regard, green nanoparticles are considered less hazardous than other forms, providing potential options for avoiding the extensive harm to the human microbiome that is prevalent with existing procedures. This review article aims to comprehensively assess the current state of knowledge on green nanoparticles related to antibiotic activity as well as their potential to assist antibiotics in treating opportunistic clinical phytopathogenic illnesses.
机会致病性微生物感染对人类健康构成重大威胁，这迫使人们使用比传统治疗方法风险更高、成本更高、效果更差的药物。这可能归因于几个因素，例如在医学中过度使用抗生素和医院环境中缺乏消毒。在这种情况下，研究人员正在寻找新的选择来对抗这种令人担忧的情况并找到解决方案。纳米颗粒目前在制药领域得到应用；然而，由于使用有毒化学物质，人们一直担心它们对人类健康的潜在危险，这使得纳米颗粒的使用对真核细胞具有高度危害性。现在正在开发多种基于纳米颗粒的技术，为合成在生产抗微生物纳米治疗药物中发挥关键作用的成分提供了重要的理解。在这方面，绿色纳米颗粒被认为比其他形式的纳米颗粒危害更小，为避免现有程序对人类微生物组造成的广泛危害提供了潜在的选择。本文综述旨在全面评估与抗生素活性相关的绿色纳米颗粒的最新知识状态及其在辅助抗生素治疗机会性临床植物病原性病方面的潜力。
