IL-4、IL-7、IL-9、NT、NRP1 可能是子宫内膜癌诊断的有用标志物。

IL-4, IL-7, IL-9, NT, NRP1 May Be Useful Markers in the Diagnosis of Endometrial Cancer.

机构信息

Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.

Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland.

出版信息

Biomolecules. 2024 Sep 1;14(9):1095. doi: 10.3390/biom14091095.

DOI:10.3390/biom14091095

PMID:39334861

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11430137/

Abstract

The search for novel endometrial cancer diagnostic biomarkers is pertinent. The purpose of this study was to determine if IL-4, IL-7, IL-9, IL-10, NT, TSP-2, and NRP1 could be used as novel, helpful markers for the detection of endometrial cancer. Ninety-three women diagnosed with endometrial cancer (EC) and sixty-six patients with noncancerous endometrial lesions (NCEL) were included in this study. ELISA was used to measure the concentrations of the proteins tested. Median serum levels of IL-4, IL-7, IL-9, NT, and NRP1 were significantly higher in the EC group compared with NCEL. The cut-off level of IL-4 was set at 802.26 pg/mL with a sensitivity of 83.87% and a specificity of 50% (AUC = 0.7, = 0.000023). The cut-off level of IL-7 was set at 133.63 ng/L with a sensitivity of 96.77% and a specificity of 75.76% (AUC = 0.91, < 0.000001). The cut-off level of IL-9 was set at 228.79 pg/mL with a sensitivity of 69.89% and a specificity of 81.82% (AUC = 0.8, < 0.000001). The cut-off level of NT was set at 275.43 pmol/L with a sensitivity of 94.62% and a specificity of 59.09% (AUC = 0.83, < 0.000001). The cut-off level of NRP1 was set at 30.37 ng/mL with a sensitivity of 81.72% and a specificity of 57.58% (AUC = 0.71, = 0.000004). This study suggests the clinical utility of IL-4, IL-7, IL-9, NT, and NRP1 in the diagnosis of endometrial cancer. Nevertheless, these biomarkers may also have prognostic or predictive value, which should be tested in future studies.

摘要

寻找新的子宫内膜癌诊断生物标志物是相关的。本研究旨在确定 IL-4、IL-7、IL-9、IL-10、NT、TSP-2 和 NRP1 是否可用作子宫内膜癌检测的新的有帮助的标志物。本研究纳入了 93 名诊断为子宫内膜癌（EC）的女性和 66 名非癌性子宫内膜病变（NCEL）患者。使用 ELISA 测量测试蛋白的浓度。与 NCEL 相比，EC 组的血清 IL-4、IL-7、IL-9、NT 和 NRP1 中位数水平显著升高。IL-4 的截断值设定为 802.26 pg/mL，灵敏度为 83.87%，特异性为 50%（AUC=0.7，=0.000023）。IL-7 的截断值设定为 133.63 ng/L，灵敏度为 96.77%，特异性为 75.76%（AUC=0.91，<0.000001）。IL-9 的截断值设定为 228.79 pg/mL，灵敏度为 69.89%，特异性为 81.82%（AUC=0.8，<0.000001）。NT 的截断值设定为 275.43 pmol/L，灵敏度为 94.62%，特异性为 59.09%（AUC=0.83，<0.000001）。NRP1 的截断值设定为 30.37 ng/mL，灵敏度为 81.72%，特异性为 57.58%（AUC=0.71，=0.000004）。本研究表明 IL-4、IL-7、IL-9、NT 和 NRP1 在子宫内膜癌诊断中有临床应用价值。然而，这些生物标志物也可能具有预后或预测价值，这应该在未来的研究中进行测试。