Kozłowski Mateusz, Borzyszkowska Dominika, Mirko Justyna, Turoń-Skrzypińska Agnieszka, Piotrowska Katarzyna, Tołoczko-Grabarek Aleksandra, Kwiatkowski Sebastian, Tarnowski Maciej, Rotter Iwona, Cymbaluk-Płoska Aneta
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland.
Cancers (Basel). 2023 Sep 30;15(19):4815. doi: 10.3390/cancers15194815.
(1) Background: It is relevant to find new diagnostic biomarkers for endometrial cancer. This study aimed to investigate whether PDGF-AB, PDGF-BB, TGF-α, EGF and ANG-2 could be considered new useful markers for diagnosis and survival of endometrial cancer. (2) Methods: A total of 93 women diagnosed with endometrial cancer (EC) and 66 patients with non-cancerous endometrial lesions (NCEL) were included in this study. (3) Results: Median serum levels of PDGF-AB, PDGF-BB, TGF-α, EGF and ANG-2 were significantly higher in the EC group compared to the NCEL group (for PDGF-AB, PDGF-BB, TGF-α and ANG-2, = 0.0000; for EGF, = 0.0186). The cut-off level of PDGF-AB was set at 127.69 pg/mL with a sensitivity of 87.1% and a specificity of 66.67% (AUC = 0.78, < 0.000001). The cut-off level of PDGF-BB was set at 207.86 ng/L with a sensitivity of 82.8% and a specificity of 75.76% (AUC = 0.85, < 0.000001). The cut-off level of TGF-α was set at 33.85 ng/L with a sensitivity of 82.8% and a specificity of 75.76% (AUC = 0.82, < 0.000001). The cut-off level of EGF was set at 934.76 pg/mL with a sensitivity of 83.87% and a specificity of 28.79% (AUC = 0.61, = 0.018472). The cut-off level of ANG-2 was set at 3120.68 pg/mL with a sensitivity of 72.04% and a specificity of 93.94% (AUC = 0.87, < 0.000001). (4) Conlusion: It was concluded that all the proteins studied could be potential diagnostic markers in endometrial cancer.
(1) 背景：寻找子宫内膜癌新的诊断生物标志物具有重要意义。本研究旨在探讨血小板衍生生长因子-AB（PDGF-AB）、血小板衍生生长因子-BB（PDGF-BB）、转化生长因子-α（TGF-α）、表皮生长因子（EGF）和血管生成素-2（ANG-2）是否可被视为子宫内膜癌诊断和生存的新的有用标志物。(2) 方法：本研究纳入了93例诊断为子宫内膜癌（EC）的女性和66例非癌性子宫内膜病变（NCEL）患者。(3) 结果：与NCEL组相比，EC组中PDGF-AB、PDGF-BB、TGF-α、EGF和ANG-2的血清中位数水平显著更高（对于PDGF-AB、PDGF-BB、TGF-α和ANG-2，P = 0.0000；对于EGF，P = 0.0186）。PDGF-AB的截断水平设定为127.69 pg/mL，灵敏度为87.1%，特异性为66.67%（AUC = 0.78，P < 0.000001）。PDGF-BB的截断水平设定为207.86 ng/L，灵敏度为82.8%，特异性为75.76%（AUC = 0.85，P < 0.000001）。TGF-α的截断水平设定为33.85 ng/L，灵敏度为82.8%，特异性为75.76%（AUC = 0.82，P < 0.000001）。EGF的截断水平设定为934.76 pg/mL，灵敏度为83.87%，特异性为28.79%（AUC = 0.61，P = 0.018472）。ANG-2的截断水平设定为3120.68 pg/mL，灵敏度为72.04%，特异性为93.94%（AUC = 0.87，P < 0.000001）。(4) 结论：得出结论，所研究的所有蛋白质都可能是子宫内膜癌的潜在诊断标志物。
