Fabiyi Kafayath, Sintondji Kevin, Agbankpe Jerrold, Assogba Phenix, Koudokpon Hornel, Lègba Boris, Gbotche Elodie, Baba-Moussa Lamine, Dougnon Victorien
Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01, Cotonou P.O. Box 2009, Benin.
Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Sciences and Techniques, University of Abomey-Calavi, Cotonou P.O. Box 1604, Benin.
Antibiotics (Basel). 2024 Aug 23;13(9):795. doi: 10.3390/antibiotics13090795.
The conventional treatment of bacterial infections with antibiotics is becoming increasingly ineffective due to the emergence of multidrug-resistant (MDR) pathogens. This literature review explores the potential of bacteriophages as an alternative or adjunctive therapy to antibiotics in combating MDR infections in Africa. This analysis focuses on current research regarding the integration of phage therapy into African healthcare, highlighting its challenges and opportunities. This review begins with the AMR crisis and the need for new treatments, then covers the history, mechanisms, benefits, and limitations of phage therapy. Key African studies are summarized, identifying major obstacles such as regulatory issues, infrastructure, and research standardization. Research efforts in West Africa that have made notable progress in bacteriophage research are highlighted. This review concludes with recommendations for policymakers, researchers, and healthcare professionals to enhance the development and use of phage therapy in Africa, aiming to reduce antibiotic resistance and improve patient outcomes. By addressing the identified challenges and leveraging the unique advantages of phages, there is potential to significantly mitigate the impact of antibiotic resistance and improve patient outcomes in Africa.
由于多重耐药（MDR）病原体的出现，使用抗生素对细菌感染进行的传统治疗正变得越来越无效。这篇文献综述探讨了噬菌体作为抗生素的替代或辅助疗法在对抗非洲多重耐药感染方面的潜力。该分析聚焦于当前有关将噬菌体疗法纳入非洲医疗保健体系的研究，突出了其面临的挑战和机遇。本综述首先介绍了抗菌药物耐药性危机以及对新治疗方法的需求，接着阐述了噬菌体疗法的历史、作用机制、益处和局限性。总结了非洲的关键研究，确定了监管问题、基础设施和研究标准化等主要障碍。重点介绍了西非在噬菌体研究方面取得显著进展的研究工作。本综述最后为政策制定者、研究人员和医疗保健专业人员提出了建议，以加强噬菌体疗法在非洲的开发和应用，旨在减少抗生素耐药性并改善患者治疗效果。通过应对已确定的挑战并利用噬菌体的独特优势，有可能显著减轻抗生素耐药性的影响并改善非洲患者的治疗效果。
