Musuroi Corina, Musuroi Silvia-Ioana, Baditoiu Luminita, Crainiceanu Zorin, Muntean Delia, Voinescu Adela, Izmendi Oana, Sirmon Alexandra, Licker Monica
Multidisciplinary Research Center of Antimicrobial Resistance, Microbiology Department, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Microbiology Laboratory, "Pius Brinzeu" County Clinical Emergency Hospital, 300723 Timisoara, Romania.
Antibiotics (Basel). 2024 Aug 30;13(9):823. doi: 10.3390/antibiotics13090823.
Infections represent a major complication for burn-injured patients. The aim of this study was to highlight the changes in the incidence and antimicrobial resistance of bacterial strains isolated from burn patients, at the end of the COVID-19 pandemic, in relation to the antibiotics used during the pandemic. A comparative analysis of the demographic data and the microorganisms identified in the clinical samples of two groups of burn patients admitted to a university hospital in Romania was carried out. The first group consisted of 48 patients and the second of 69 patients, hospitalized in January-August 2020 and 2023, respectively. The bacterial species with the highest incidence were , , spp. The significant changes between 2023 and 2020 are reflected in the increase in the frequency of non-fermentative Gram-negative bacteria, especially , and the increase in antimicrobial resistance of and spp. spp. did not change in frequency (7%), but there was a significant increase in the incidence of strains with pan-drug resistant behaviour to antibiotics (40%), including colistin. The phenomenon can be explained by the selection of specimens carrying multiple resistance genes, as a result of antibiotic treatment during the COVID-19 period. The post-pandemic antimicrobial resistance detected in burn patients indicates the need for permanent surveillance of the resistance trends, primarily due to the limited therapeutic options available for these patients.
感染是烧伤患者的主要并发症。本研究的目的是突出在新冠疫情结束时，从烧伤患者中分离出的细菌菌株的发病率和抗菌药物耐药性的变化，以及与疫情期间使用的抗生素的关系。对罗马尼亚一家大学医院收治的两组烧伤患者临床样本中的人口统计学数据和鉴定出的微生物进行了比较分析。第一组由48名患者组成，第二组由69名患者组成，分别于2020年1月至8月和2023年住院。发病率最高的细菌种类为 、 、 属。2023年和2020年之间的显著变化体现在非发酵革兰氏阴性菌频率的增加，尤其是 ，以及 属和 属抗菌药物耐药性的增加。 属的频率没有变化（7%），但对包括黏菌素在内的抗生素具有泛耐药行为的 菌株的发病率显著增加（40%）。这种现象可以解释为在新冠疫情期间由于抗生素治疗导致携带多种耐药基因的样本被选择。在烧伤患者中检测到的疫情后抗菌药物耐药性表明需要对耐药趋势进行持续监测，主要是因为这些患者可用的治疗选择有限。
