Dakhode Shubham Yashwant, Kim Woo Sub, Kim Hyun Jin, Lee Seung Yeol
Department of Orthopaedics, District General Hospital, Bhandara 441904, India.
Department of Orthopaedic Surgery, Myongji Hospital, Hanyang University College of Medicine, 55, Hwasu-ro 14beon-gil, Deogyang-gu, Gyeonggi-do, Goyang-si 10475, Republic of Korea.
Antibiotics (Basel). 2024 Sep 4;13(9):841. doi: 10.3390/antibiotics13090841.
Taurolidine, known for its broad-spectrum antimicrobial properties and low toxicity, has shown promise in reducing infections in various surgical settings. However, it has not been extensively evaluated in orthopedic surgery. This study assessed the efficacy of taurolidine irrigation in reducing surgical site infections in patients undergoing ankle fracture surgery. A retrospective review was conducted for patients >20 years old who underwent ankle fracture surgery between March 2016 and March 2023, with follow-ups exceeding 6 months. Patients were classified into the following two groups: those who underwent normal saline (NS) irrigation and those who underwent taurolidine irrigation. Minor infections were defined as requiring additional oral antibiotics postoperatively, while major infections were characterized by hospitalization or reoperation due to infection within 3 months. Of 844 patients, 688 were included. The taurolidine group ( = 328) had a significant reduction in minor infections (7.3% vs. 22.5%, odds ratio = 0.410, = 0.028) compared to the NS group ( = 360). Major infections were fewer in the NS group (1.2% vs. 0%, = 0.051), but the number of cases was too small for reliable analysis. Taurolidine irrigation significantly reduces the occurrence of minor infections in ankle fracture surgeries when compared to normal saline irrigation.
牛磺罗定以其广谱抗菌特性和低毒性而闻名，已显示出在各种手术环境中减少感染的前景。然而，它在骨科手术中尚未得到广泛评估。本研究评估了牛磺罗定冲洗在减少踝关节骨折手术患者手术部位感染方面的疗效。对2016年3月至2023年3月期间接受踝关节骨折手术且随访超过6个月的20岁以上患者进行了回顾性研究。患者被分为以下两组：接受生理盐水（NS）冲洗的患者和接受牛磺罗定冲洗的患者。轻微感染定义为术后需要额外口服抗生素，而严重感染的特征是在3个月内因感染而住院或再次手术。在844例患者中，纳入了688例。与NS组（n = 360）相比，牛磺罗定组（n = 328）的轻微感染显著减少（7.3%对22.5%，优势比 = 0.410，P = 0.028）。NS组的严重感染较少（1.2%对0%，P = 0.051），但病例数太少，无法进行可靠分析。与生理盐水冲洗相比，牛磺罗定冲洗显著降低了踝关节骨折手术中轻微感染的发生率。
