ESKAPE 病原体对菌血症的影响：意大利南部一家大型医院的三年监测研究
Impact of ESKAPE Pathogens on Bacteremia: A Three-Year Surveillance Study at a Major Hospital in Southern Italy.
作者信息
De Prisco Mariagrazia, Manente Roberta, Santella Biagio, Serretiello Enrica, Dell'Annunziata Federica, Santoro Emanuela, Bernardi Francesca F, D'Amore Chiara, Perrella Alessandro, Pagliano Pasquale, Boccia Giovanni, Franci Gianluigi, Folliero Veronica
机构信息
Clinical Pathology and Microbiology Unit, San Giovanni di Dio and Ruggi D'Aragona University Hospital, 84131 Salerno, Italy.
U.O.C. of Virology and Microbiology, University Hospital "Luigi Vanvitelli", 80138 Naples, Italy.
出版信息
Antibiotics (Basel). 2024 Sep 21;13(9):901. doi: 10.3390/antibiotics13090901.
BACKGROUND/OBJECTIVES: ESKAPE pathogens (, , , , , and spp.) pose a serious public health threat as they are resistant to multiple antimicrobial agents. Bloodstream infections (BSIs) caused by ESKAPE bacteria have high mortality rates due to the limited availability of effective antimicrobials. This study aimed to evaluate the prevalence and susceptibility of ESKAPE pathogens causing BSIs over three years in a large tertiary hospital in Salerno.
METHODS
Conducted at the Clinical Microbiology Laboratory of San Giovanni di Dio e ''Ruggi D'Aragona'' Hospital from January 2020 to December 2022, blood culture samples from different departments were incubated in the BD BACTEC™ system for 5 days. Species identification was performed using MALDI-TOF MS, and antimicrobial resistance patterns were determined by the VITEK2 system.
RESULTS
Out of 3197 species isolated from positive blood cultures, 38.7% were ESKAPE bacteria. Of these, 59.9% were found in blood culture samples taken from men, and the most affected age group was those aged >60 years. (70.6%). was the main BSI pathogen (26.3%), followed by (15.8%). Significant resistance rates were found, including 35% of being resistant to oxacillin and over 90% of being resistant to carbapenems.
CONCLUSIONS
These results highlight the urgent need for antimicrobial stewardship programs to prevent incurable infections.
背景/目的：ESKAPE病原体（粪肠球菌、屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌和铜绿假单胞菌）对多种抗菌药物具有耐药性，对公众健康构成严重威胁。由ESKAPE细菌引起的血流感染（BSIs）由于有效抗菌药物有限，死亡率很高。本研究旨在评估在萨勒诺一家大型三级医院中，ESKAPE病原体导致血流感染的三年患病率和药敏情况。
方法
于2020年1月至2022年12月在圣乔瓦尼迪奥和“鲁吉·德阿拉贡纳”医院的临床微生物实验室进行，来自不同科室的血培养样本在BD BACTEC™系统中培养5天。使用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）进行菌种鉴定，通过VITEK2系统确定抗菌药物耐药模式。
结果
从阳性血培养中分离出的3197个菌种中，38.7%为ESKAPE细菌。其中，59.9%在男性血培养样本中发现，受影响最严重的年龄组是60岁以上人群（70.6%）。金黄色葡萄球菌是主要的血流感染病原体（26.3%），其次是肺炎克雷伯菌（15.8%）。发现了显著的耐药率，包括35%的金黄色葡萄球菌对苯唑西林耐药，超过90%的鲍曼不动杆菌对碳青霉烯类耐药。
结论
这些结果凸显了迫切需要开展抗菌药物管理计划以预防无法治愈的感染。
Zotero 插件