Debreczeni-Máté Zsanett, Freihat Omar, Törő Imre, Simon Mihály, Kovács Árpád, Sipos David
Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7621 Pécs, Hungary.
Department of Public Health, College of Health Science, Abu Dhabi University, Abu Dhabi P.O. Box 59911, United Arab Emirates.
Cancers (Basel). 2024 Sep 20;16(18):3200. doi: 10.3390/cancers16183200.
11C-Methionine (MET) is a widely utilized amino acid tracer in positron emission tomography (PET) imaging of primary brain tumors. 11C-MET PET offers valuable insights for tumor classification, facilitates treatment planning, and aids in monitoring therapeutic response. Its tracer properties allow better delineation of the active tumor volume, even in regions that show no contrast enhancement on conventional magnetic resonance imaging (MRI). This review focuses on the role of MET-PET in brain glioma imaging. The introduction provides a brief clinical overview of the problems of high-grade and recurrent gliomas. It discusses glioma management, radiotherapy planning, and the difficulties of imaging after chemoradiotherapy (pseudoprogression or radionecrosis). The mechanism of MET-PET is described. Additionally, the review encompasses the application of MET-PET in the context of primary gliomas, addressing its diagnostic precision, utility in tumor classification, prognostic value, and role in guiding biopsy procedures and radiotherapy planning.
11C-蛋氨酸（MET）是正电子发射断层扫描（PET）成像中广泛应用于原发性脑肿瘤的氨基酸示踪剂。11C-MET PET为肿瘤分类提供了有价值的见解，有助于治疗计划制定，并有助于监测治疗反应。其示踪特性能够更好地勾勒出活性肿瘤体积，即使在传统磁共振成像（MRI）上无对比增强的区域也是如此。本综述聚焦于MET-PET在脑胶质瘤成像中的作用。引言部分简要介绍了高级别和复发性胶质瘤的临床问题。讨论了胶质瘤的管理、放射治疗计划以及放化疗后的成像困难（假性进展或放射性坏死）。描述了MET-PET的机制。此外，本综述还涵盖了MET-PET在原发性胶质瘤中的应用，阐述了其诊断准确性、在肿瘤分类中的效用、预后价值以及在指导活检程序和放射治疗计划中的作用。
