英国和澳大利亚关于接受免疫抑制药物治疗患者癌症的联合研究。
Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs.
作者信息
Kinlen L J, Sheil A G, Peto J, Doll R
出版信息
Br Med J. 1979 Dec 8;2(6203):1461-6. doi: 10.1136/bmj.2.6203.1461.
Abstract
A collaborative study including centres in the United Kingdom, Australia, and New Zealand was instituted in 1970 to determine the incidence of cancer in patients treated for at least three months with azathioprine, cyclophosphamide, or chlorambucil. Follow-up of 3823 renal transplant recipients showed an almost 60-fold increase of non-Hodgkin's lymphoma together with an excess of squamous-cell skin cancer and mesenchymal tumours. A series of 1349 patients without transplants showed an excess of the same tumours, though to a less extent. These preliminary findings provide no clear evidence that immunosuppressive drugs produce the increased risk of most of the common cancers that might be expected from the simplest interpretation of impaired "immunosurveillance."
摘要
1970年开展了一项包括英国、澳大利亚和新西兰各中心的合作研究，以确定接受硫唑嘌呤、环磷酰胺或苯丁酸氮芥治疗至少三个月的患者的癌症发病率。对3823名肾移植受者的随访显示，非霍奇金淋巴瘤的发病率几乎增加了60倍，同时鳞状细胞皮肤癌和间叶组织肿瘤也有所增加。1349名未接受移植的患者也出现了相同肿瘤的增加，不过程度较轻。这些初步发现没有提供明确证据表明免疫抑制药物会增加大多数常见癌症的风险，而按照对受损“免疫监视”的最简单解释，本预计会出现这种情况。
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