Martínez-Herrera Erick, Galindo-Oseguera Evelyn, Castillo-Cruz Juan, Fuentes-Venado Claudia Erika, Gasca-López Gilberto Adrián, Calzada-Mendoza Claudia C, Ocharan-Hernández Esther, Zúñiga-Cruz Carlos Alberto, Farfán-García Eunice D, Arellano-Ramírez Alfredo, Pinto-Almazán Rodolfo
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Ciudad de Mexico 11340, Mexico.
Fundación Vithas, Grupo Hospitalario Vithas, 28043 Madrid, Spain.
Biomedicines. 2024 Sep 7;12(9):2037. doi: 10.3390/biomedicines12092037.
Traumatic brain injury (TBI) is a major cause of death and disability, with a rising incidence in recent years. Factors such as age, sex, hypotension, low score on the Glasgow Coma Scale, use of invasive mechanical ventilation and vasopressors, etc., have been associated with mortality caused by TBI. The aim of this study was to identify the clinical and sociodemographic characteristics that influence the mortality or survival of patients with TBI in a tertiary care hospital in Mexico.
A sample of 94 patients aged 18 years or older, from both sexes, with an admitting diagnosis of mild-to-severe head trauma, with initial prehospital treatment, was taken. Data were extracted from the Single Registry of Patients with TBI at the Ixtapaluca Regional High Specialty Hospital (HRAEI). Normality tests were used to decide on the corresponding statistical analysis.
No factors associated with mortality were found; however, survival analysis showed that the presence of seizures, aggregate limb trauma, and subjects with diabetes mellitus, heart disease or patients with four concomitant comorbidities had 100% mortality. In addition, having seizures in the prehospital setting increased the risk of mortality four times. Although they did not have a direct association with mortality, they significantly decreased survival. A larger sample size is probably required to obtain an association with mortality.
These results reflect the severity of the clinical situation in this population and, although no risk factors were identified, they enlighten us about the conditions presented by patients who died.
创伤性脑损伤(TBI)是死亡和残疾的主要原因,近年来发病率呈上升趋势。年龄、性别、低血压、格拉斯哥昏迷量表评分低、使用有创机械通气和血管升压药等因素与TBI导致的死亡率相关。本研究的目的是确定影响墨西哥一家三级护理医院中TBI患者死亡率或生存率的临床和社会人口学特征。
选取94例年龄在18岁及以上、男女不限、入院诊断为轻至重度头部创伤且接受过初始院前治疗的患者作为样本。数据从伊克斯塔帕卢卡地区高级专科医院(HRAEI)的TBI患者单一登记处提取。使用正态性检验来决定相应的统计分析方法。
未发现与死亡率相关的因素;然而,生存分析表明,出现癫痫、肢体复合伤以及患有糖尿病、心脏病或有四种合并症的患者死亡率为100%。此外,院前出现癫痫会使死亡风险增加四倍。虽然它们与死亡率没有直接关联,但会显著降低生存率。可能需要更大的样本量才能得出与死亡率的关联。
这些结果反映了该人群临床情况的严重性,尽管未确定风险因素,但它们让我们了解了死亡患者所呈现的状况。