Lee Esther, Kim Joaane, Rahman Sadiq, Daksla Neil, Caldwell William, Bergese Sergio
Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA.
Biomedicines. 2024 Sep 9;12(9):2046. doi: 10.3390/biomedicines12092046.
Lower back pain (LBP) is a widely prevalent global health issue, affecting over half a billion people and remaining the leading cause of years lived with disability (YLDs). LBP significantly impacts healthcare systems, with substantial costs related to surgical procedures and lost workdays. Vertebrogenic back pain (VBP), characterized by specific clinical symptoms and associated with Modic changes (MC) in vertebral endplates, best seen on MRI, is a significant subset of LBP. This paper explores the pathophysiology, diagnosis, and current reports and studies focusing on VBP and the role of basivertebral nerve (BVN) ablation as a therapeutic intervention. Multiple studies, including randomized controlled trials (RCTs) and meta-analyses, demonstrate the efficacy of BVN ablation in reducing pain and improving function in patients with chronic LBP associated with MC.
下背痛（LBP）是一个广泛存在的全球性健康问题，影响着超过5亿人，并且仍然是导致残疾生存年数（YLDs）的主要原因。LBP对医疗系统产生重大影响，与手术程序和工作日损失相关的成本巨大。椎源性背痛（VBP）以特定的临床症状为特征，与椎体终板的Modic改变（MC）相关，在MRI上最易观察到，是LBP的一个重要子集。本文探讨了VBP的病理生理学、诊断以及当前关注VBP的报告和研究，以及椎基底神经（BVN）消融作为一种治疗干预措施的作用。多项研究，包括随机对照试验（RCTs）和荟萃分析，证明了BVN消融在减轻与MC相关的慢性LBP患者的疼痛和改善功能方面的有效性。
