Department of Neurology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.
Department of Neurology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
Medicina (Kaunas). 2024 Aug 23;60(9):1378. doi: 10.3390/medicina60091378.
: A family history of Parkinson's disease (PD) is an important risk factor for developing PD. Because only a few studies have investigated the clinical characteristics of PD patients based on family history, this study compared the clinical characteristics of PD patients with and without a family history of PD. : The study involved 356 patients with de novo PD. The data on the patients' PD family histories were obtained from the patients and their caregivers. Motor and non-motor PD symptoms were assessed using the appropriate scales. : Out of the 356 PD patients, 26 (7.3%) had a family history of PD. Compared with patients without a family history of PD, those with a family history of PD tended to be younger at diagnosis (67.9 years vs. 62.2 years, respectively; = 0.009) and exhibited significantly more severe rigidity ( = 0.036). Motor subtype was not different between the PD patients with and without a family history. PD patients with a family history experienced significantly fewer falls/cardiovascular symptoms within the Non-Motor Symptoms Scale domains ( = 0.001) compared to their counterparts, although this was not statistically significant upon adjusting for age ( = 0.119). : In de novo PD patients, having a family history of PD is associated with a younger age at diagnosis and more severe rigidity.
家族帕金森病史（PD）是发生 PD 的重要危险因素。由于仅有少数研究基于家族史调查了 PD 患者的临床特征，本研究比较了有家族 PD 病史和无家族 PD 病史的 PD 患者的临床特征。
这项研究纳入了 356 例新发 PD 患者。患者及其照料者提供了有关 PD 家族史的数据。采用适当的量表评估了患者的运动和非运动 PD 症状。
在 356 例 PD 患者中，26 例（7.3%）有 PD 家族史。与无 PD 家族史的患者相比，有 PD 家族史的患者的诊断年龄更小（分别为 67.9 岁和 62.2 岁，P = 0.009），且僵硬症状更为严重（P = 0.036）。有家族史和无家族史的 PD 患者的运动亚型无差异。在非运动症状量表的各领域中，有家族史的 PD 患者的跌倒/心血管症状明显更少（P = 0.001），尽管在校正年龄后这一差异无统计学意义（P = 0.119）。
在新发 PD 患者中，有 PD 家族史与诊断年龄较小和更严重的僵硬相关。
