Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Romania.
Department of Endocrinology, Mures County Hospital, Gheorghe Marinescu Street 42, 540142 Targu Mures, Romania.
Medicina (Kaunas). 2024 Aug 24;60(9):1387. doi: 10.3390/medicina60091387.
: The anti-Müllerian hormone (AMH) is a crucial biomarker in regulating ovarian follicle development and female fertility. AMH levels predict ovarian responses in in vitro fertilization (IVF) cycles, helping clinicians tailor treatment strategies. This study aims to determine whether thyroid autoimmunity, age, body mass index (BMI), sexual hormone levels, and 25-hydroxyvitamin D levels influence serum AMH in non-polycystic-ovary-syndrome (PCOS) euthyroid women. : This retrospective cross-sectional study examined 52 female patients at Zygota Fertility Clinic between 2018 and 2022. Women aged 20-45 years with regular menstrual cycles were included, while conditions such as abnormal thyroid-stimulating hormone (TSH) levels, PCOS, and systemic autoimmune diseases were excluded. A number of parameters were measured in the study, including the subjects' age, BMI, 25-hydroxyvitamin D, serum free thyroxine (fT4), TSH, various antibodies, and a range of reproductive hormones. An analysis of the relationships between AMH and other variables was conducted using Spearman's correlation coefficient, and an assessment of the impact of confounding factors on AMH levels was conducted using a multivariable linear regression model. : The results revealed significant negative correlations between AMH levels and age (rho: -0.484, < 0.001) and follicle-stimulating hormone (FSH) (rho: -0.550, < 0.001), while positive correlations existed between AMH and estradiol (rho: 0.352, = 0.011) and total testosterone (rho: 0.542, < 0.001). No significant correlations were found between AMH levels and BMI, LH, or 25-hydroxyvitamin D. : In this study, ovarian reserve was influenced by age, estradiol, and total testosterone in non-PCOS euthyroid women undergoing IVF. Conversely, BMI and vitamin D status did not significantly impact AMH levels. In order to better understand and possibly manage ovarian reserve, a holistic approach is absolutely essential, taking into account age, weight, hormonal balance, nutrition, and thyroid health.
抗缪勒管激素（AMH）是调节卵巢卵泡发育和女性生育能力的关键生物标志物。AMH 水平可预测体外受精（IVF）周期中的卵巢反应，帮助临床医生制定治疗策略。本研究旨在确定甲状腺自身免疫、年龄、体重指数（BMI）、性激素水平和 25-羟维生素 D 水平是否会影响非多囊卵巢综合征（PCOS）甲状腺功能正常女性的血清 AMH。
本回顾性横断面研究于 2018 年至 2022 年期间在 Zygota 生育诊所检查了 52 名女性患者。纳入年龄在 20-45 岁、月经周期规律的女性，排除甲状腺刺激激素（TSH）水平异常、PCOS 和系统性自身免疫性疾病等情况。研究中测量了一些参数，包括受试者的年龄、BMI、25-羟维生素 D、血清游离甲状腺素（fT4）、TSH、各种抗体和一系列生殖激素。使用 Spearman 相关系数分析 AMH 与其他变量之间的关系，使用多元线性回归模型评估混杂因素对 AMH 水平的影响。
结果显示，AMH 水平与年龄（rho：-0.484，<0.001）和卵泡刺激素（FSH）（rho：-0.550，<0.001）呈显著负相关，而与雌二醇（rho：0.352，=0.011）和总睾酮（rho：0.542，<0.001）呈正相关。AMH 水平与 BMI、LH 或 25-羟维生素 D 无显著相关性。
在这项研究中，非 PCOS 甲状腺功能正常的接受 IVF 的女性中，卵巢储备受到年龄、雌二醇和总睾酮的影响。相反，BMI 和维生素 D 状况对 AMH 水平没有显著影响。为了更好地了解和可能管理卵巢储备，需要采取全面的方法，考虑年龄、体重、激素平衡、营养和甲状腺健康。
