Crotti Silvia, Cruciani Deborah, Sabbatucci Michela, Spina Sara, Piscioneri Vincenzo, Torricelli Martina, Calcaterra Roberta, Farina Claudio, Pisano Luigi, Papini Manuela
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati" (IZSUM), 06126 Perugia, Italy.
Department Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
J Clin Med. 2024 Sep 17;13(18):5493. doi: 10.3390/jcm13185493.
In recent decades, globalization and international migration have increased the spread of infectious agents, including dermatophytes. Although considered minor infections, dermatophytoses are highly contagious, and they significantly reduce the quality of life, inducing itching, burning, sleep disturbances, and even depressive states. Moreover, the increasing resistance to antifungals threats the public health and burdens the costs for the healthcare system. DermaGenius Resistance Multiplex real-time PCR assay allowed to analyze the terbinafine susceptibility/resistance of 172 strains, which were isolated from human and animal samples collected from 2016 to May 2024 and previously identified by Sanger sequencing. All the 11 animal strains belonged to the / complex and tested terbinafine sensitive. Out of 161 human strains, 9 (5.6%) showed terbinafine resistance and 7 (4.3%) were identified as . This study provides preliminary data about behavior toward antifungals in animals and finalizes the scientific information currently available about human strains, highlighting the importance of the One Health concept. Moreover, it supports the relevant role of as an emerging dermatophyte with high proportion of terbinafine resistance.
近几十年来，全球化和国际移民增加了包括皮肤癣菌在内的传染源的传播。尽管皮肤癣菌病被认为是轻微感染，但具有高度传染性，会显著降低生活质量，引发瘙痒、灼痛、睡眠障碍，甚至导致抑郁状态。此外，对抗真菌药物的耐药性不断增加，威胁着公共卫生，给医疗系统带来成本负担。DermaGenius Resistance Multiplex实时聚合酶链反应检测能够分析172株菌株对特比萘芬的敏感性/耐药性，这些菌株是从2016年至2024年5月采集的人类和动物样本中分离出来的，之前已通过桑格测序法进行鉴定。所有11株动物菌株均属于/复合体，对特比萘芬检测敏感。在161株人类菌株中，9株（5.6%）表现出对特比萘芬耐药，7株（4.3%）被鉴定为。本研究提供了关于动物对抗真菌药物反应的初步数据，并完善了目前关于人类菌株的科学信息，凸显了“同一健康”概念的重要性。此外，它支持作为一种新兴皮肤癣菌且对特比萘芬耐药比例高的相关作用。
