Reis Fabrício Moreira, Ferrari Eduarda Baccarin, Reis Nayrana Soares do Carmo, Costa Fabiana Lourenço, Morimoto Paula Naomi, Maurício Alejandra Del Carmen Villanueva, Hueb João Carlos, Bazan Rodrigo, Banin Vanessa Burgugi, Barretti Pasqual, Martin Luis Cuadrado, Zanati Bazan Silméia Garcia
Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil.
Department of Neurology, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil.
J Clin Med. 2024 Sep 19;13(18):5539. doi: 10.3390/jcm13185539.
The coronary artery calcium score and left atrial volume have been shown to predict the incidence of acute myocardial infarction and death from cardiovascular disease in patients undergoing peritoneal dialysis. However, the association between these factors has not been well-established. This cross-sectional, prospective, single-center study was conducted on patients undergoing outpatient peritoneal dialysis, who were followed up at a university hospital between March 2018 and August 2019. The coronary artery calcium score was calculated based on cardiovascular computed tomography findings. The score was "positive" when it was ≥100 Agatston and "negative" when it was <100 Agatston. The left atrial volume was obtained using the biplane disc method at the end of the left ventricular systole, and then it was indexed to the body surface. Forty-four patients were evaluated. They had an age [mean (range)] of 56 (43-65) years and had been on dialysis therapy for 11.7 (6.8-25.4) months. Univariate analysis revealed a relationship between the coronary artery calcium score and left atrial volume index and the following variables: age, diabetes, overhydration, pulse wave velocity, E/A ratio, and left ventricular mass index. In multivariate logistic regression analysis, only the left atrial volume index was independently associated with a positive coronary artery calcium score. The left atrial volume index was associated with a positive coronary artery calcium score in patients on peritoneal dialysis, regardless of other factors. It may be a useful risk marker for coronary artery disease in this population.
冠状动脉钙化评分和左心房容积已被证明可预测接受腹膜透析患者的急性心肌梗死发病率和心血管疾病死亡率。然而，这些因素之间的关联尚未完全确立。本横断面、前瞻性、单中心研究针对接受门诊腹膜透析的患者开展，这些患者于2018年3月至2019年8月在一家大学医院接受随访。冠状动脉钙化评分基于心血管计算机断层扫描结果计算得出。当评分≥100阿加斯顿单位时为“阳性”，<100阿加斯顿单位时为“阴性”。左心房容积在左心室收缩末期采用双平面圆盘法获取，然后根据体表面积进行指数化。共评估了44例患者。他们的年龄[均值（范围）]为56（43 - 65）岁，接受透析治疗11.7（6.8 - 25.4）个月。单因素分析显示冠状动脉钙化评分和左心房容积指数与以下变量之间存在关联：年龄、糖尿病、水钠潴留、脉搏波速度、E/A比值和左心室质量指数。在多因素逻辑回归分析中，只有左心房容积指数与冠状动脉钙化评分阳性独立相关。无论其他因素如何，左心房容积指数与腹膜透析患者的冠状动脉钙化评分阳性相关。它可能是该人群冠状动脉疾病的一个有用风险标志物。
