Papadakis Dimitrios-Dorotheos, Politou Marianna, Pittaras Theodoros, Stergiou Ioanna E, Koutsoukou Antonia, Kompoti Maria, Vasileiadis Ioannis
Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Haematology Laboratory-Blood Bank, Aretaieion Hospital, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
J Clin Med. 2024 Sep 21;13(18):5603. doi: 10.3390/jcm13185603.
: Through the past several years, a constant interaction has been implicated between complement and coagulation cascades. SARS-CoV-2 infection and bacterial sepsis are potent activators of both cascades. This study aims to compare the extent of complement and intrinsic coagulation pathway activation (and the interplay between them) among patients with COVID-19 and bacterial sepsis. : Serum and plasma samples were collected from 25 ICU patients (11 patients with COVID-19 and 14 patients with bacterial sepsis) at two time points (on admission and either on improvement or deterioration). The activities of coagulation factors XI and XII and complement factors C3a and C5a were measured at both time points. : The activities of factors XI and XII were increased in both groups of patients and at both time points. However, there were no statistically significant differences between SARS-CoV-2 and bacterial sepsis patients. On the other hand, both C3a and C5a were significantly higher in the COVID-19 group on admission. This correlation was preserved on reassessment. : Complement activation seems to be more enhanced in COVID-19 than bacterial sepsis. However, the lack of statistical significance in factors XI and XII indicates t the presence of additional pathways for complement activation in SARS-CoV-2 infection.
在过去几年中，补体和凝血级联反应之间一直存在着持续的相互作用。严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染和细菌性败血症是这两种级联反应的强效激活剂。本研究旨在比较新型冠状病毒肺炎（COVID-19）患者和细菌性败血症患者补体和内源性凝血途径的激活程度（以及它们之间的相互作用）。：在两个时间点（入院时以及病情改善或恶化时）从25名重症监护病房（ICU）患者（11名COVID-19患者和14名细菌性败血症患者）采集血清和血浆样本。在两个时间点均检测凝血因子XI和XII以及补体因子C3a和C5a的活性。：两组患者在两个时间点时因子XI和XII的活性均升高。然而，SARS-CoV-2感染患者和细菌性败血症患者之间无统计学显著差异。另一方面，COVID-19组患者入院时C3a和C5a均显著更高。重新评估时这种相关性依然存在。：与细菌性败血症相比，COVID-19中的补体激活似乎更强。然而，因子XI和XII缺乏统计学显著性表明SARS-CoV-2感染中存在补体激活的其他途径。
