Wenzl Alice, Wenzl Rene, Gstoettner Manuela, Kuessel Lorenz, Husslein Heinrich, Heine Jana, Sandrieser Lejla, Bekos Christine, Perricos-Hess Alexandra
Department of Obstetrics and Gynecology, Spitalspartner Ordensklinikum Linz und Konventhospital Barmherzige Brueder, Seilerstaette 2, 4020 Linz, Austria.
Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
J Clin Med. 2024 Sep 23;13(18):5641. doi: 10.3390/jcm13185641.
This study investigated the long-term effects of the surgical removal of endometriotic lesions on quality of life in endometriosis patients. A sub-analysis explored different subtypes of endometriosis, hormonal influence, and the need for reoperation. The study was conducted at the Certified Endometriosis Center of the Medical University of Vienna. Included in the study were patients who had undergone the complete surgical removal of endometriotic lesions between 2014 and 2018. Patients were asked to complete the Endometriosis Health Profile-30 preoperatively, at the short-term follow-up (six to ten weeks postoperatively), and at the long-term follow-up (median of 48 months postoperatively). A total of 87 patients completed the Endometriosis Health Profile-30 at the three time points. At the long-term follow-up, the reoperation rate was 8.0%. Significant improvements in the overall quality of life ( < 0.001; median decrease from 45.0 to 11.7) and in the categories of "pain", "control and powerlessness", "social support", "emotional well-being", and "self-image" at the long-term follow-up compared to preoperative values were observed (-values < 0.01). The sub-analysis showed that patients with deep-infiltrating endometriosis ( < 0.001; median decrease from 49.2 to 10.0) and adenomyosis ( < 0.02; median decrease from 37.5 to 0.0) had the most pronounced long-term postsurgical benefits in terms of quality of life. Patients with ( < 0.001; median decrease from 45.0 to 1.7) and without ( < 0.001; median decrease from 45.42 to 12.5) hormonal influence showed significant improvements in overall quality of life compared to preoperative values. Patients without reoperation demonstrated improved long-term quality of life compared to the preoperative ( < 0.001; median decrease from 45.8 to 9.6) and short-term follow-up results ( < 0.005; median decrease from 19.2 to 9.6). Participants who underwent reoperation showed no improvement in quality of life at the long-term follow-up. : The surgical removal of endometriotic lesions has a positive long-term impact on the quality of life, as measured by Endometriosis Health Profile-30.
本研究调查了手术切除子宫内膜异位症病灶对子宫内膜异位症患者生活质量的长期影响。一项亚分析探讨了子宫内膜异位症的不同亚型、激素影响以及再次手术的必要性。该研究在维也纳医科大学认证的子宫内膜异位症中心进行。纳入研究的患者为2014年至2018年间接受了子宫内膜异位症病灶完全手术切除的患者。要求患者在术前、短期随访（术后6至10周）和长期随访（术后中位时间48个月）时完成子宫内膜异位症健康状况问卷-30。共有87名患者在这三个时间点完成了子宫内膜异位症健康状况问卷-30。在长期随访中，再次手术率为8.0%。与术前值相比，长期随访时总体生活质量有显著改善（<0.001；中位数从45.0降至11.7），在“疼痛”、“控制与无助感”、“社会支持”、“情绪健康”和“自我形象”等类别中也有显著改善（-值<0.01）。亚分析表明，深部浸润型子宫内膜异位症患者（<0.001；中位数从49.2降至10.0）和子宫腺肌病患者（<0.02；中位数从37.5降至0.0）在生活质量方面术后长期获益最为显著。有激素影响的患者（<0.0
