Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Int J Mol Sci. 2024 Sep 11;25(18):9831. doi: 10.3390/ijms25189831.
Traditionally, garlic has a valuable role in preventing and reducing the incidence of many diseases and pathophysiological disorders. Consequently, some researchers have focused on the beneficial cardiovascular properties of diallyl trisulfide (DATS), the most potent polysulfide isolated from garlic. Therefore, in this review, we collected the available data on DATS, its biochemical synthesis, metabolism and pharmacokinetics, and gathered the current knowledge and the role of DATS in cardiovascular diseases. Overall, this review summarizes the cardioprotective effects of DATS and brings together all previous findings on its protective molecular mechanisms, which are mainly based on the potent anti-apoptotic, anti-inflammatory, and antioxidant potential of this polysulfide. Our review is an important cornerstone for further basic and clinical research on DATS as a new therapeutic agent for the treatment of numerous heart diseases.
传统上，大蒜在预防和减少许多疾病和病理生理紊乱的发生方面具有重要作用。因此，一些研究人员关注二烯丙基三硫化物（DATS）的有益心血管特性，DATS 是从大蒜中分离出的最有效的多硫化物。因此，在这篇综述中，我们收集了关于 DATS 的可用数据，包括其生化合成、代谢和药代动力学，并汇集了 DATS 在心血管疾病中的现有知识和作用。总的来说，本综述总结了 DATS 的心脏保护作用，并汇集了以前关于其保护分子机制的所有发现，这些机制主要基于这种多硫化物的强大抗凋亡、抗炎和抗氧化潜力。我们的综述是进一步进行 DATS 基础和临床研究的重要基石，因为 DATS 是治疗许多心脏病的新治疗剂。
