Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Int J Mol Sci. 2024 Sep 14;25(18):9922. doi: 10.3390/ijms25189922.
Among the most deadly malignancies that strike women worldwide, ovarian cancer is still one of the most common. The primary factor affecting a patient's survival is early lesion discovery. Unfortunately, because ovarian cancer is a sneaky illness that usually manifests as nonspecific symptoms only in advanced stages, its early detection and screening are challenging. A lot of research is being conducted on effective methods of diagnosing and treating ovarian cancer. Recently, non-coding RNAs (ncRNAs) have gained great popularity, which are considered to be the main regulators of many cellular processes, especially those occurring in cancer. LncRNAs are also being studied for their therapeutic use in the treatment of ovarian cancer and their use in diagnostics and as indicators of poor prognosis. In this article, we reviewed lncRNAs described in the literature that may play an important role in ovarian cancer.
在全球范围内威胁女性生命的最致命恶性肿瘤中，卵巢癌仍然是最常见的癌症之一。影响患者生存的主要因素是早期病变的发现。不幸的是，由于卵巢癌是一种狡猾的疾病，通常仅在晚期表现出非特异性症状，因此早期发现和筛查具有挑战性。目前正在进行大量关于有效诊断和治疗卵巢癌的方法的研究。最近，非编码 RNA（ncRNA）受到了广泛关注，它们被认为是许多细胞过程的主要调节剂，尤其是在癌症中发生的过程。lncRNA 也正在研究其在卵巢癌治疗中的治疗用途，以及在诊断和作为预后不良指标中的用途。在本文中，我们综述了文献中描述的可能在卵巢癌中发挥重要作用的 lncRNA。
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