Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Int J Mol Sci. 2024 Sep 19;25(18):10081. doi: 10.3390/ijms251810081.
A preliminary in silico screening of 94 compounds, including colchicine, caffeine, gramine, and their derivatives, was conducted to identify potential herbicides, insecticides, and fungicides. Among the compounds tested, only gramine and its 13 derivatives exhibited potential activity. These compounds were further tested against eight species of insects, three species of weeds, and four species of fungi. All of the tested alkaloids were found to be ineffective as herbicides and insecticides, but they did exhibit some fungicidal activity. Four gramine derivatives showed some activity against , , , and .
初步的计算机筛选了 94 种化合物，包括秋水仙碱、咖啡因、禾草灵及其衍生物，以鉴定潜在的除草剂、杀虫剂和杀菌剂。在测试的化合物中，只有禾草灵及其 13 种衍生物表现出潜在的活性。这些化合物进一步测试了对 8 种昆虫、3 种杂草和 4 种真菌的活性。所有测试的生物碱都被证明无效作为除草剂和杀虫剂，但它们确实表现出一些杀菌活性。四种禾草灵衍生物对、、、和表现出一定的活性。
