Lamberth Clemens
Syngenta Crop Protection AG, Stein, Switzerland.
Amino Acids. 2016 Apr;48(4):929-940. doi: 10.1007/s00726-016-2176-5. Epub 2016 Jan 22.
Several naturally occurring amino acid derivatives display significant activities against weeds, fungi and insects: some of them have been even commercialized and are applied as crop protection agents. The 53 most important amino acid natural products with such efficacy are presented in this review together with their natural source, mode of action and biological activity. The diversity of the manifold bacterial, fungal and plantal sources of these compounds is impressive as well as their completely different structural scaffolds, ranging from cyclopeptides via unique non-proteinogenic amino acids to peptidyl nucleosides, the broad range of target enzymes from several different biochemical pathways, which they inhibit and also the plethora of different weeds, fungi and insects they are able to control.
几种天然存在的氨基酸衍生物对杂草、真菌和昆虫具有显著活性：其中一些甚至已商业化，并用作作物保护剂。本文综述了53种具有这种功效的最重要的氨基酸天然产物，以及它们的天然来源、作用方式和生物活性。这些化合物多样的细菌、真菌和植物来源令人印象深刻，其结构支架也完全不同，从环肽到独特的非蛋白质氨基酸，再到肽基核苷；它们抑制的多种不同生化途径中的靶标酶范围广泛，以及它们能够控制的大量不同杂草、真菌和昆虫。
