Jeon Soomin, Lee Hayera, Lee Jae-Ho, Lee Kippeum, Hong Dongki, Park Soo-Dong, Shim Jae-Jung, Lee Jung-Lyoul, Lee Jaehwan, Joo Jong-Cheon
R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Gyeonggi-do, Republic of Korea.
Department of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University; Iksan 54538, Jeonbuk, Republic of Korea.
Life (Basel). 2024 Sep 9;14(9):1136. doi: 10.3390/life14091136.
Arthritis is mainly a geriatric disease that causes joint pain and lowers the quality of life. This clinical trial was performed to evaluate the efficacy of Thunb. (HY-LL) in alleviating joint pain. Six candidate anti-inflammatory components including regaloside A were identified in HY-LL using HPLC analysis. All participants were assigned to the HY-LL or the placebo group and took tablets twice a day for 12 weeks. As a result, pain VAS and K-WOMAC total scores significantly decreased after 12 weeks compared to the baseline in the HY-LL group, with a statistically significant difference between the two groups ( = 0.043, 0.043). The K-WOMAC sub-scores for pain and function showed a statistically significant improvement in the HY-LL group compared to the placebo group ( = 0.023, 0.047). Furthermore, the participants' overall quality of life improved after 12 weeks of HY-LL consumption ( = 0.024). However, no significant differences were observed in the blood biomarkers. Therefore, this study demonstrated the positive effect of 12 weeks of HY-LL consumption on joint pain and quality of life.
关节炎主要是一种老年疾病，会导致关节疼痛并降低生活质量。进行这项临床试验是为了评估土大黄（HY-LL）缓解关节疼痛的疗效。使用高效液相色谱分析在HY-LL中鉴定出包括瑞加洛苷A在内的六种候选抗炎成分。所有参与者被分配到HY-LL组或安慰剂组，每天服用两次片剂，持续12周。结果，与基线相比，HY-LL组在12周后疼痛视觉模拟评分（VAS）和K-WOMAC总分显著降低，两组之间存在统计学显著差异（P = 0.043，0.043）。与安慰剂组相比，HY-LL组的K-WOMAC疼痛和功能子评分有统计学显著改善（P = 0.023，0.047）。此外，服用HY-LL 12周后参与者的总体生活质量有所改善（P = 0.024）。然而，血液生物标志物未观察到显著差异。因此，本研究证明了服用HY-LL 12周对关节疼痛和生活质量有积极影响。
