Stroffolini Giacomo, Atzori Cristiana, Imperiale Daniele, Trunfio Mattia, Di Perri Giovanni, Calcagno Andrea
Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don Angelo Sempreboni 5, Negrar, 37024 Verona, Italy.
Unit of Neurology, Ospedale Maria Vittoria, ASL Città di Torino, Via Luigi Cibrario, 72, 10144 Torino, Italy.
Microorganisms. 2024 Aug 24;12(9):1758. doi: 10.3390/microorganisms12091758.
People living with HIV (PLWH) may present atypical neurological complications. Recently, autoimmune manifestations of the central nervous system (CNS) have been described. We retrospectively described the features of PLWH presenting with acute neurological symptoms with positive anti-CNS antibodies. We analyzed relevant CSF characteristics. Twelve patients were identified, with demyelinating, inflammatory, or no MRI lesions. We observed CSF inflammatory features. Aspecific CSF anti-CNS antibodies were found in all subjects and a specific antibody (second-level blotting panel) was found in one. The cases presented a slow resolution of symptoms with sequelae. More studies are needed to better describe the spectrum and prognosis of autoimmune CNS diseases in PLWH.
人类免疫缺陷病毒感染者（PLWH）可能出现非典型神经并发症。最近，已描述了中枢神经系统（CNS）的自身免疫表现。我们回顾性描述了伴有抗CNS抗体阳性的急性神经症状的PLWH的特征。我们分析了相关的脑脊液特征。共确定了12例患者，其存在脱髓鞘、炎症性或无MRI病变。我们观察到脑脊液炎症特征。所有受试者均发现非特异性脑脊液抗CNS抗体，1例发现特异性抗体（二级印迹法检测）。这些病例症状缓解缓慢且有后遗症。需要更多研究来更好地描述PLWH中自身免疫性中枢神经系统疾病的范围和预后。
