Department of Radiology, Hospital Universitário Cassiano Antônio de Moraes da Universidade Federal do Espírito Santo - HUCAM/UFES/EBSERH, Brazil.
Department of Infectious Diseases, Hospital Universitário Cassiano Antônio de Moraes da Universidade Federal do Espírito Santo - HUCAM/UFES/EBSERH, Brazil.
AIDS Rev. 2020 Jul 8;22(2):112-122. doi: 10.24875/AIDSRev.20000132.
The increase of CD8 + T lymphocytes in the perivascular spaces of patients with HIV encephalopathy has been reported in some studies. CD8 + T lymphocyte encephalitis was first described in 2013 and then a few other similar cases were published. We proposed to analyze the clinical, MR imaging, and histopathology findings of CD8 + T lymphocyte encephalitis. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyzes protocol using the PubMed, Scopus, Lilacs, and IBECS databases up to February 3, 2018. Seven articles were included, two case series and five case reports. A total of 19 individuals were evaluated. MRI showed alterations in the white matter signal in all cases. Histopathology showed a predominance of CD8 + T lymphocytes. The findings described so far may resemble the inflammatory immune reconstitution syndrome. New studies on the subject are needed in an attempt to characterize the differences between these two entities.
一些研究报告称，HIV 性脑病患者血管周围间隙的 CD8+T 淋巴细胞增多。CD8+T 淋巴细胞脑炎于 2013 年首次描述，随后发表了其他一些类似病例。我们建议分析 CD8+T 淋巴细胞脑炎的临床、MR 成像和组织病理学发现。根据系统评价和荟萃分析的首选报告项目协议，我们使用 PubMed、Scopus、Lilacs 和 IBECS 数据库进行了系统综述，截至 2018 年 2 月 3 日。共纳入 7 篇文章，2 篇病例系列，5 篇病例报告。共评估了 19 个人。所有病例的 MRI 均显示白质信号改变。组织病理学显示 CD8+T 淋巴细胞为主。到目前为止描述的这些发现可能类似于炎症性免疫重建综合征。需要对该主题进行新的研究，以试图确定这两个实体之间的差异。
