Teacoe Dumitru Alin, Cormoș Roxana Cristina, Toma Diana Adela, Ștef Laura, Cucerea Manuela, Muțiu Irina, Chicea Radu, Popescu Dragoș, Chicea Eugen Dan, Boicean Adrian Gheorghe, Galiș Radu, Ognean Maria Livia
Faculty of Medicine, Lucian Blaga University Sibiu, 550169 Sibiu, Romania.
Clinical County Emergency Hospital Sibiu, 550245 Sibiu, Romania.
Microorganisms. 2024 Sep 10;12(9):1869. doi: 10.3390/microorganisms12091869.
spp. is rarely found in neonatal early-onset sepsis (EOS) etiology. However, candidemia is associated with increased mortality and morbidity, as in late-onset sepsis. Congenital candidiasis may present as a mucocutaneous infection or, more rarely, as a systemic infection in term and preterm infants. This paper presents case reports of two cases of congenital systemic candidiasis (CSC) caused by and a review of the data in the literature. An electronic search of PubMed, Scopus, and Google Scholar was performed to identify publications on congenital candidiasis. Both neonates were male, born vaginally, with risk factors for congenital candidiasis. One of the infants was born at term and presented with an almost generalized maculopapular rash at birth and congenital candidemia; parenteral fluconazole was used successfully. The other infant was born prematurely at 28 weeks of gestation; blood culture, gastric aspirate, and maternal vaginal cultures sampled at birth were positive for Liver and kidney involvement became apparent on the third day of life, while lung involvement was clinically evident on the fourth day. Prolonged parenteral fluconazole was administered due to multiple organ involvement and persistent candidemia. Our experience with the presented cases, similar to data in the literature, suggests that CSC may occur at any gestational age, with various clinical pictures, sometimes mimicking bacterial sepsis, and even in the absence of the rash. Careful anamnesis and a high index of suspicion are important for the prompt recognition and treatment of CSC, optimizing the short- and long-term outcomes. Further research should focus on CSC to improve its diagnosis.
该菌属在新生儿早发型败血症（EOS）病因中很少见。然而，念珠菌血症与死亡率和发病率增加有关，就像在晚发型败血症中一样。先天性念珠菌病可能表现为皮肤黏膜感染，或更罕见地，在足月儿和早产儿中表现为全身感染。本文介绍了两例由该菌属引起的先天性全身念珠菌病（CSC）的病例报告，并对文献数据进行了综述。通过对PubMed、Scopus和谷歌学术进行电子检索，以确定关于先天性念珠菌病的出版物。两名新生儿均为男性，经阴道分娩，有先天性念珠菌病的危险因素。其中一名婴儿为足月儿，出生时出现几乎全身性的斑丘疹，并有先天性念珠菌血症；成功使用了静脉注射氟康唑。另一名婴儿在妊娠28周时早产；出生时采集的血培养、胃吸出物和母亲阴道培养物对该菌属呈阳性。出生第三天肝脏和肾脏受累明显，而第四天肺部受累在临床上明显。由于多器官受累和持续性念珠菌血症，给予了长时间的静脉注射氟康唑。我们对所呈现病例的经验，与文献数据相似，表明CSC可能发生在任何孕周，有各种临床表现，有时会模仿细菌性败血症，甚至在没有皮疹的情况下也会发生。仔细的病史采集和高度的怀疑指数对于CSC的及时识别和治疗很重要，可优化短期和长期结果。进一步的研究应聚焦于CSC以改善其诊断。
