Shope Chelsea, Ritter Alexandra, Karlin Samantha, Lee Lara Wine, Cotton Colleen H
College of Medicine, Medical University of South Carolina, Charleston, SC.
Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.
Neoreviews. 2023 Mar 1;24(3):e175-e180. doi: 10.1542/neo.24-3-e175.
Congenital cutaneous candidiasis (CCC) is a rare condition, which typically affects premature and very low birthweight neonates. Affected infants present with a diffuse rash of variable morphology, which can appear as peeling, sloughing desquamation; maculopapular lesions; or, less commonly, pustules, vesicles, or bullae. Due to the varied nature of the clinical presentation, the diagnosis of CCC can be quite difficult but critically important because early treatment with intravenous fluconazole can prevent disease progression. In this review, we summarize the epidemiology, pathogenesis, clinical presentation, evaluation, and management of CCC.
先天性皮肤念珠菌病（CCC）是一种罕见疾病，通常影响早产儿和极低出生体重儿。患病婴儿会出现形态各异的弥漫性皮疹，可表现为脱皮、剥脱性脱屑；斑丘疹性损害；或较少见的脓疱、水疱或大疱。由于临床表现的多样性，CCC的诊断可能相当困难，但至关重要，因为早期静脉注射氟康唑治疗可预防疾病进展。在本综述中，我们总结了CCC的流行病学、发病机制、临床表现、评估和管理。
