Selby P L, Peacock M, Barkworth S A, Brown W B, Taylor G A
Clin Sci (Lond). 1985 Sep;69(3):265-71. doi: 10.1042/cs0690265.
The early effects of sex steroid therapy were assessed in 28 normal post-menopausal women, 18 treated with ethinyloestradiol and 10 with norethisterone. There was a reduction in the fasting urinary excretion of both calcium and hydroxyproline with both treatments, indicating reduced bone resorption. This was apparent after 1 week of therapy but became more marked after 3 weeks. These changes were not accompanied by any changes in plasma levels of calcitonin or parathyroid hormone. Patients receiving ethinyloestradiol showed a marked increase in plasma 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentration but this was explicable entirely in terms of increased plasma levels of vitamin D binding protein. There was no change in the free plasma level of 1,25(OH)2D. Patients treated with norethisterone showed no increase in plasma concentrations of 1,25(OH)2D. We conclude that both ethinyloestradiol and norethisterone have a rapid and similar effect in reducing bone resorption. This is not mediated via the plasma levels of the calcium regulating hormones.
对28名绝经后正常女性进行了性类固醇疗法的早期效果评估，其中18名接受乙炔雌二醇治疗，10名接受炔诺酮治疗。两种治疗方法均使钙和羟脯氨酸的空腹尿排泄量减少，表明骨吸收减少。治疗1周后就很明显，但3周后更为显著。这些变化并未伴随降钙素或甲状旁腺激素血浆水平的任何变化。接受乙炔雌二醇治疗的患者血浆1,25 - 二羟维生素D（1,25-(OH)₂D）浓度显著升高，但这完全可以用维生素D结合蛋白血浆水平升高来解释。血浆中游离的1,25(OH)₂D水平没有变化。接受炔诺酮治疗的患者血浆1,25(OH)₂D浓度没有升高。我们得出结论，乙炔雌二醇和炔诺酮在减少骨吸收方面具有快速且相似的效果。这不是通过钙调节激素的血浆水平介导的。
