Zofková I, Röjdmark S, Kancheva R L
Institute of Endocrinology, Prague, Czech Republic.
J Endocrinol Invest. 1993 May;16(5):323-7. doi: 10.1007/BF03348845.
In postmenopausal women PTH suppression by exogenous calcium is reduced. To test whether this finding might be caused by estrogen deficiency 9 postmenopausal women were given transdermal estradiol (E2) treatment for 3 months at a dose of 100 micrograms/day. PTH reactivity to iv administration of CaCl2 was determined before and at the end of the E2-treatment period. Compliance to treatment was checked by determination of serum levels of E2 and FSH. The E2 level rose from 0.1 +/- 0.02 (mean +/- SE) to 0.46 +/- 0.10 mmol/l p < 0.01), whereas the corresponding FSH level declined from 77.5 +/- 7.4 to 33.9 +/- 5.7 U/l p < 0.01). This suggests good compliance. At the end of E2-treatment period calcium administration induced a higher PTH suppression as compared with control value (the PTH decremental area 2123 +/- 270 vs 1253 +/- 253 ng/l x min, p < 0.05), although a lower calcemic response was attained (the Ca incremental area 32.6 +/- 6.1 vs 47.4 +/- 4.5 mmol/ml x min, p < 0.05). These results imply that parathyroid glands are dependent on an adequate estrogen provision to respond normally to serum calcium changes.
绝经后女性对外源性钙的甲状旁腺激素（PTH）抑制作用减弱。为了检验这一发现是否可能由雌激素缺乏引起，9名绝经后女性接受了为期3个月的经皮雌二醇（E2）治疗，剂量为每日100微克。在E2治疗期开始前和结束时，测定了PTH对静脉注射氯化钙的反应性。通过测定血清E2和促卵泡激素（FSH）水平来检查治疗依从性。E2水平从0.1±0.02（平均值±标准误）升至0.46±0.10毫摩尔/升（p<0.01），而相应的FSH水平从77.5±7.4降至33.9±5.7U/升（p<0.01）。这表明依从性良好。在E2治疗期结束时，与对照值相比，补钙引起了更高的PTH抑制（PTH减量面积2123±270对1253±253纳克/升×分钟，p<0.05），尽管血钙反应较低（钙增量面积32.6±6.1对47.4±4.5毫摩尔/毫升×分钟，p<0.05）。这些结果表明，甲状旁腺依赖于充足的雌激素供应来对血清钙变化做出正常反应。
