Selby P L, Peacock M
Clin Endocrinol (Oxf). 1986 Nov;25(5):543-7. doi: 10.1111/j.1365-2265.1986.tb03607.x.
Transdermal oestradiol, 100 micrograms/d, was used to treat 11 women suffering from postmenopausal symptoms. After 3 weeks therapy there was a significant rise in the plasma oestradiol into the premenopausal range and a significant fall in plasma FSH level and symptom score. Bone resorption, assessed by urinary excretion of calcium and hydroxyproline, decreased significantly while plasma alkaline phosphatase activity remained constant. There was a significant fall in plasma calcium and phosphate but the plasma concentrations of PTH, calcitonin and calcitriol and the urinary excretion of cAMP were unchanged. Plasma levels of vitamin D binding protein, albumin and globulin were unaltered, and blood pressure did not rise. These effects were similar to those found in postmenopausal women with oral ethinyloestradiol, 30 micrograms/d, (Selby et al., 1985), apart from those on plasma vitamin D binding protein, total calcitriol, albumin, globulin, tubular reabsorption of phosphate and blood pressure, changes which probably arise from a direct action of oral oestrogen on the liver.
采用每日100微克的经皮雌二醇治疗11名患有绝经后症状的女性。治疗3周后，血浆雌二醇显著升高至绝经前范围，血浆促卵泡激素水平和症状评分显著下降。通过尿钙和羟脯氨酸排泄评估的骨吸收显著降低，而血浆碱性磷酸酶活性保持不变。血浆钙和磷酸盐显著下降，但血浆甲状旁腺激素、降钙素和骨化三醇浓度以及尿中环磷酸腺苷排泄未发生变化。血浆维生素D结合蛋白、白蛋白和球蛋白水平未改变，血压也未升高。这些效应与每日口服30微克乙炔雌二醇的绝经后女性中发现的效应相似（塞尔比等人，1985年），除了对血浆维生素D结合蛋白、总骨化三醇、白蛋白、球蛋白、磷酸盐的肾小管重吸收和血压的影响，这些变化可能是口服雌激素对肝脏直接作用引起的。
