Hall J E, Ehrhart I C, Hofman W F
Crit Care Med. 1985 Dec;13(12):1015-9. doi: 10.1097/00003246-198512000-00006.
Perfluorocarbon (PFC) emulsions are promising oxygen-carrying blood supplements for the treatment of shock and in organ preservation for transplantation. We used the isolated, blood-perfused, canine right lower lung lobe (RLL) to determine the effect of a PFC emulsion, Oxypherol (FC-43), upon lung fluid balance and hemodynamics. Eighteen RLLs were divided into three equal groups, one of which was infused with a bovine serum albumin (BSA) solution to 10% of the total perfusate volume, and two of which were infused with Oxypherol to 10% and 20% of the final blood volume, respectively. At 145 min after infusion, there was no significant difference among the three groups in pH, blood gases, and lobar compliance. Arterial pressure and lobar vascular resistance were significantly (p less than .05) greater in the 20% Oxypherol group than in the BSA group. PFC-related changes in lobar permeability were determined by measuring the pulmonary filtration coefficient (Kf), which was not significantly different among groups. Thus, Oxypherol did not increase microvascular permeability (i.e., lung edema).
全氟碳（PFC）乳剂有望成为治疗休克和用于移植器官保存的携氧血液补充剂。我们使用离体的、血液灌注的犬右下肺叶（RLL）来确定一种PFC乳剂Oxypherol（FC - 43）对肺液体平衡和血流动力学的影响。18个RLL被分为三组，其中一组输注牛血清白蛋白（BSA）溶液至灌注液总体积的10%，另外两组分别输注Oxypherol至最终血容量的10%和20%。输注后145分钟，三组在pH、血气和肺叶顺应性方面无显著差异。20% Oxypherol组的动脉压和肺叶血管阻力显著（p小于0.05）高于BSA组。通过测量肺滤过系数（Kf）来确定与PFC相关的肺叶通透性变化，各组之间无显著差异。因此，Oxypherol不会增加微血管通透性（即肺水肿）。
