Lin Wei-Chih, Hoe Boon-Chin, Li Xianming, Lian Daizheng, Zeng Xiaowei
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.
Kemin (China) Technologies Co., Ltd., Zhuhai 519040, China.
Pharmaceutics. 2024 Sep 13;16(9):1208. doi: 10.3390/pharmaceutics16091208.
Glucose, a primary energy source derived from animals' feed ration, is crucial for their growth, production performance, and health. However, challenges such as metabolic stress, oxidative stress, inflammation, and gut microbiota disruption during animal production practices can potentially impair animal glucose metabolism pathways. Phytochemicals, probiotics, prebiotics, and trace minerals are known to change the molecular pathway of insulin-dependent glucose metabolism and improve glucose uptake in rodent and cell models. These compounds, commonly used as animal feed additives, have been well studied for their ability to promote various aspects of growth and health. However, their specific effects on glucose uptake modulation have not been thoroughly explored. This article focuses on glucose metabolism is on discovering alternative non-pharmacological treatments for diabetes in humans, which could have significant implications for developing feed additives that enhance animal performance by promoting insulin-dependent glucose metabolism. This article also aims to provide information about natural materials that impact glucose uptake and to explore their potential use as non-antibiotic feed additives to promote animal health and production. Further exploration of this topic and the materials involved could provide a basis for new product development and innovation in animal nutrition.
葡萄糖是来自动物饲料的主要能量来源，对其生长、生产性能和健康至关重要。然而，在动物生产过程中，诸如代谢应激、氧化应激、炎症和肠道微生物群破坏等挑战可能会损害动物的葡萄糖代谢途径。已知植物化学物质、益生菌、益生元及微量矿物质可改变胰岛素依赖性葡萄糖代谢的分子途径，并改善啮齿动物和细胞模型中的葡萄糖摄取。这些化合物通常用作动物饲料添加剂，其促进生长和健康各方面的能力已得到充分研究。然而，它们对葡萄糖摄取调节的具体作用尚未得到充分探索。本文关注葡萄糖代谢，旨在发现人类糖尿病的替代性非药物治疗方法，这可能对开发通过促进胰岛素依赖性葡萄糖代谢来提高动物性能的饲料添加剂具有重要意义。本文还旨在提供有关影响葡萄糖摄取的天然物质的信息，并探索它们作为非抗生素饲料添加剂促进动物健康和生产的潜在用途。对该主题及相关材料的进一步探索可为动物营养领域的新产品开发和创新提供基础。
